ArticleAging2011
Induction and persistence of radiation-induced DNA damage is more pronounced in young animals than in old animals.
Article in Aging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- An Evaluation of the Potential Radiosensitization Effect of Spherical Gold Nanoparticles to Induce Cellular Damage Using Different Radiation Qualities.Molecules (Basel, Switzerland) · 2025Article
- Article
- Molecular and cellular basis of the dose-rate-dependent adverse effects of radiation exposure in animal models. Part I: Mammary gland and digestive tract.Journal of radiation research · 2023Review
- Total marrow irradiation reduces organ damage and enhances tissue repair with the potential to increase the targeted dose of bone marrow in both young and old mice.Frontiers in oncology · 2022Article
- Methods for induction and assessment of intestinal permeability in rodent models of radiation injury.Methods in cell biology · 2022Article
- The Phosphorylated Form of the Histone H2AX (γH2AX) in the Brain from Embryonic Life to Old Age.Molecules (Basel, Switzerland) · 2021Review
- Article
- HSCs transdifferentiate primarily to pneumonocytes in radiation-induced lung damage repair.Aging · 2021Article
- Differential expression of DNA-dependent protein kinase catalytic subunit in the brain of neonatal mice and young adult mice.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2020Article
- The Radioprotective Effect of Procaine and Procaine-Derived Product Gerovital H3 in Lymphocytes from Young and Aged Individuals.Oxidative medicine and cellular longevity · 2020Article
- Radiation-induced unrepairable DSBs: their role in the late effects of radiation and possible applications to biodosimetry.Journal of radiation research · 2018Review
- Low dose radiation effects on the brain - from mechanisms and behavioral outcomes to mitigation strategies.Cell cycle (Georgetown, Tex.) · 2017Article
- Dose-dependent effects of gamma radiation on the early zebrafish development and gene expression.PloS one · 2017Article
- Longitudinal microcomputed tomography-derived biomarkers for lung metastasis detection in a syngeneic mouse model: added value to bioluminescence imaging.Laboratory investigation; a journal of technical methods and pathology · 2017Article
- Article
- Post-training gamma irradiation-enhanced contextual fear memory associated with reduced neuronal activation of the infralimbic cortex.Behavioural brain research · 2016Article
- Long-term Autophagy and Nrf2 Signaling in the Hippocampi of Developing Mice after Carbon Ion Exposure.Scientific reports · 2015Article
- Longitudinal in vivo microcomputed tomography of mouse lungs: No evidence for radiotoxicity.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- High throughput measurement of γH2AX DSB repair kinetics in a healthy human population.PloS one · 2015Article
- DNA damage focus analysis in blood samples of minipigs reveals acute partial body irradiation.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Younger individuals are more prone to develop cancer upon ionizing radiation (IR) exposure. Radiation-induced tumors are associated with inefficient repair of IR-induced DNA damage and genome instability. Phosphorylation of histone H2AX (γ-H2AX) is the initial event in repair of IR-induced DNA damage on the chromatin flanking the DNA strand breaks. This step is crucially important for the repair of DNA strand breaks and for the maintenance of genome stability. We studied the molecular underpinnings of the age-related IR effects using an animal model. By assaying for IR-induced γ-H2AX foci we analyzed the induction and repair of the DNA strand breaks in spleen, thymus, liver, lung, kidney, cerebellum, hippocampus, frontal cortex and olfactory bulb of 7, 14, 24, 30 and 45 days old male and female mice as a function of age. We demonstrate that tissues of younger animals are much more susceptible to IR-induced DNA damage. Younger animals exhibited higher levels of γ-H2AX formation which partially correlated with cellular proliferation and expression of DNA repair proteins. Induction and persistence of γ-H2AX foci was the highest in lymphoid organs (thymus and spleen) of 7 and 14 day old mice. The lowest focal induction was seen in lung and brain of young animals. The mechanisms of cell and tissue-specificity of in vivo IR responses need to be further dissected. This study provides a roadmap for the future analyses of DNA damage and repair induction in young individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.