ArticleNucleic acids research2011
Molecular insights into miRNA processing by Arabidopsis thaliana SERRATE.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 85 citations in OpenAlex.
- SERRATE Regulates Floral Meristem Activity by Antagonizing SHOOT MERISTEMLESS and Repressing Cytokinin Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Rice and shine: a review of miRNA-mediated responses to abiotic stress inFrontiers in plant science · 2026Review
- Plant microRNA maturation and function.Nature reviews. Molecular cell biology · 2026Review
- How intrinsically disordered proteins order plant gene silencing.Trends in genetics : TIG · 2024Review
- Article
- Phylogenetic analyses of seven protein families refine the evolution of small RNA pathways in green plants.Plant physiology · 2023Article
- Intrinsically disordered proteins SAID1/2 condensate on SERRATE for dual inhibition of miRNA biogenesis in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- An antisense intragenic lncRNA SEAIRa mediates transcriptional and epigenetic repression ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- microRNA production inFrontiers in plant science · 2023Review
- MicroRNA: noncoding but still coding, another example of self-catalysis.Functional & integrative genomics · 2022Review
- Multiple Functions of MiRNAs inLife (Basel, Switzerland) · 2022Review
- Structural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex.Nature communications · 2022Article
- Identification of Pri-miRNA Stem-Loop Interacting Proteins in Plants Using a Modified Version of the Csy4 CRISPR Endonuclease.International journal of molecular sciences · 2022Article
- PRP4KA phosphorylates SERRATE for degradation via 20Science advances · 2022Article
- Structural basis of microRNA processing by Dicer-like 1.Nature plants · 2021Article
- Regulation of pri-MIRNA processing: mechanistic insights into the miRNA homeostasis in plant.Plant cell reports · 2021Review
- Molecular insights into miRNA processing by Arabidopsis thaliana SERRATE.Nucleic acids research · 2021Article
- Functional characterization of thePlant diversity · 2021Article
- Phase separation of SERRATE drives dicing body assembly and promotes miRNA processing in Arabidopsis.Nature cell biology · 2021Article
- Degradation of SERRATE via ubiquitin-independent 20S proteasome to survey RNA metabolism.Nature plants · 2020Article
Corrections and comments
- Expression of concern
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In plant, primary transcripts (pri-miRNAs) transcribed from miRNA genes by RNA polymerase II are first processed into stem-loop pre-miRNAs and further chopped into ∼21 nt long miRNAs by RNase III-like enzyme DCL1. SERRATE (SE) protein is an essential component for miRNA processing by assisting DCL1 for accurate cleavage. Here we report the crystal structure of Arabidopsis SE core (residues 194-543) at 2.7 Å. SE core adopts the 'walking man-like' topology with N-terminal α helices, C-terminal non-canonical zinc-finger domain and novel Middle domain resembling the leading leg, the lagging leg and the body, respectively. Pull-down assay shows that SE core provides the platform for HYL1 and DCL1 binding, whereas in vitro RNA binding and in vivo mutant rescue experiments suggest that the non-canonical zinc-finger domain coupled with C-terminal tail binds miRNA precursors. SE presumably works as a scaffold-like protein capable of binding both protein and RNA to guide the positioning of miRNA precursor toward DCL1 catalytic site within miRNA processing machinery in plant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.