ArticleExperimental physiology2011
Human skeletal muscle feed arteries studied in vitro: the effect of temperature on α(1)-adrenergic responsiveness.
Article in Experimental physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Tissue oxygen saturation during hyperthermic progressive central hypovolemia.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Trial
- Passive leg movement-induced vasodilation and exercise-induced sympathetic vasoconstriction.Autonomic neuroscience : basic & clinical · 2022Article
- Regional thermal hyperemia in the human leg: Evidence of the importance of thermosensitive mechanisms in the control of the peripheral circulation.Physiological reports · 2021Article
- Radial artery spasm: reviews and updates.Irish journal of medical science · 2020Review
- Vasodilatory and vascular mitochondrial respiratory function with advancing age: evidence of a free radically mediated link in the human vasculature.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Vasoreactivity of the Murine External Jugular Vein and Carotid Artery.Journal of vascular research · 2020Article
- Article
- Vascular mitochondrial respiratory function: the impact of advancing age.American journal of physiology. Heart and circulatory physiology · 2018Article
- Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy.Journal of visualized experiments : JoVE · 2017Article
- TRPVExperimental physiology · 2017Article
- Mechanisms for the control of local tissue blood flow during thermal interventions: influence of temperature-dependent ATP release from human blood and endothelial cells.Experimental physiology · 2017Article
- Impact of age on the vasodilatory function of human skeletal muscle feed arteries.American journal of physiology. Heart and circulatory physiology · 2016Article
- Local temperature-sensitive mechanisms are important mediators of limb tissue hyperemia in the heat-stressed human at rest and during small muscle mass exercise.American journal of physiology. Heart and circulatory physiology · 2015Article
- Human cardiovascular responses to passive heat stress.Comprehensive Physiology · 2015Review
- α1- and α2-adrenergic responsiveness in human skeletal muscle feed arteries: the role of TRPV ion channels in heat-induced sympatholysis.American journal of physiology. Heart and circulatory physiology · 2014Article
- Cardiac, skeletal, and smooth muscle mitochondrial respiration: are all mitochondria created equal?American journal of physiology. Heart and circulatory physiology · 2014Article
- Haemodynamic responses to dehydration in the resting and exercising human leg.European journal of applied physiology · 2013Article
- α1-Adrenergic responsiveness in human skeletal muscle feed arteries: the impact of reducing extracellular pH.Experimental physiology · 2013Article
- Heat and α1-adrenergic responsiveness in human skeletal muscle feed arteries: the role of nitric oxide.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Effect of heat stress on cardiac output and systemic vascular conductance during simulated hemorrhage to presyncope in young men.American journal of physiology. Heart and circulatory physiology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Heat and cold exposure can decrease and increase total peripheral resistance, respectively, in humans. With unique access to human skeletal muscle feed arteries, we sought both to characterize these vessels and to determine the interaction between temperature and α(1)-adrenergic receptor responsiveness. We hypothesized that α(1)-mediated vasocontraction of human feed arteries would be attenuated in response to 39 or 35°C. Skeletal muscle feed arteries were harvested from thirty-two human volunteers and studied using isometric techniques. Vessel function was assessed using KCl, sodium nitroprusside (SNP), phenylephrine (PE) and ACh dose-response curves to characterize non-receptor- and receptor-mediated vasocontraction and vasorelaxation. Single doses of PE (1 mm) and KCl (100 mm) were administered at 37°C and then, in a balanced design, repeated at both 35 and 39°C. The KCl and PE dose-response curves elicited significant vasocontraction (2009 ± 407 and 1974 ± 508 mg developed tension, respectively), whereas SNP and ACh induced the expected vasorelaxation (102 ± 6 and 73 ± 10% relaxation, respectively). Altering the temperature had no effect on inherent smooth muscle function (KCl response), but both a reduction (35°C) and an increase in temperature (39°C) decreased the vasocontractile response to 1 mm PE (37°C, 1478 ± 338 mg; 35°C, 546 ± 104 mg; and 39°C, 896 ± 202 mg; P < 0.05) or across PE dose (P < 0.05, 35 and 39 versus 37°C). Despite clear heterogeneity between both the human volunteers and the feed arteries themselves, this novel approach to the procurement of human vessels revealed a robust 'inverted U' response to altered temperature, such that α(1)-mediated vasocontraction was attenuated with either warming or cooling.
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