ArticleThe Journal of biological chemistry2011
Tissue-specific gene targeting by the multiprotein mammalian DREAM complex.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- A DP-like transcription factor protein interacts with E2fl1 to regulate meiosis in Tetrahymena thermophila.Cell cycle (Georgetown, Tex.) · 2018Article
- Protein interaction networks at the host-microbe interface inRoyal Society open science · 2017Article
- Novel functions for the transcription factor E2F4 in development and disease.Cell cycle (Georgetown, Tex.) · 2016Review
- Glucocorticoid receptor-mediatedBone reports · 2016Article
- SWI/SNF-Mediated Lineage Determination in Mesenchymal Stem Cells Confers Resistance to Osteoporosis.Stem cells (Dayton, Ohio) · 2015Article
- Article
- The CHR site: definition and genome-wide identification of a cell cycle transcriptional element.Nucleic acids research · 2014Article
- Cooperative activation of tissue-specific genes by pRB and E2F1.Cancer research · 2013Article
- Essential role of ARID2 protein-containing SWI/SNF complex in tissue-specific gene expression.The Journal of biological chemistry · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The mammalian DP, RB-like, E2F, and MuvB-like proteins (DREAM) complex, whose key components include p130 and E2F4, plays a fundamental role in repression of cell cycle-specific genes during growth arrest. Mammalian DREAM is well conserved with Drosophila and Caenorhabditis elegans complexes that repress pivotal developmental genes, but the mammalian complex has been thought to exist only in quiescent cells and not to be linked with development. However, new findings here identify tissue-specific promoters repressed by DREAM in proliferating precursors, revealing a new connection between control of growth arrest and terminal differentiation. Mechanistically, tissue-specific promoter occupation by DREAM is dependent on the integrity of a repressor form of the SWI/SNF chromatin-remodeling complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.