ArticleGenes & development2011
An evolutionarily 'young' lysine residue in histone H3 attenuates transcriptional output in Saccharomyces cerevisiae.
Article in Genes & development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Investigation of the acetic acid stress response inMicrobial cell (Graz, Austria) · 2023Article
- Lysine Methylation Modulates the Interaction of Archaeal Chromatin Protein Cren7 With DNA.Frontiers in microbiology · 2022Article
- Dynamic Histone H3 Modifications Regulate Meiosis Initiation via Respiration.Frontiers in cell and developmental biology · 2021Article
- Review
- Methylation of two-component response regulator MtrA in mycobacteria negatively modulates its DNA binding and transcriptional activation.The Biochemical journal · 2020Article
- Systematic genetic and proteomic screens during gametogenesis identify H2BK34 methylation as an evolutionary conserved meiotic mark.Epigenetics & chromatin · 2020Article
- Article
- Revealing eukaryotic histone-modifying mechanisms through bacterial infection.Seminars in immunopathology · 2020Review
- Article
- Identification of Tension Sensing Motif of Histone H3 in Saccharomyces cerevisiae and Its Regulation by Histone Modifying Enzymes.Genetics · 2016Article
- Mycobacteria modulate host epigenetic machinery by Rv1988 methylation of a non-tail arginine of histone H3.Nature communications · 2015Article
- Histone core modifications regulating nucleosome structure and dynamics.Nature reviews. Molecular cell biology · 2014Review
- H3R42me2a is a histone modification with positive transcriptional effects.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Review
- Chromatin and transcription in yeast.Genetics · 2012Review
- Systematic dissection of roles for chromatin regulators in a yeast stress response.PLoS biology · 2012Article
- Histone H4 lysine 20 of Saccharomyces cerevisiae is monomethylated and functions in subtelomeric silencing.Biochemistry · 2011Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
The DNA entry and exit points on the nucleosome core regulate the initial invasion of the nucleosome by factors requiring access to the underlying DNA. Here we describe in vivo consequences of eliminating a single protein-DNA interaction at this position through mutagenesis of histone H3 Lys 42 to alanine. This substitution has a dramatic effect on the Saccharomyces cerevisiae transcriptome in both the transcriptional output and landscape of mRNA species produced. We attribute this in part to decreased histone H3 occupancy at transcriptionally active loci, leading to enhanced elongation. Additionally we show that this lysine is methylated in vivo, and genetic studies of methyl-lysine mimics suggest that this modification may be crucial in attenuating gene expression. Interestingly, this site of methylation is unique to Ascomycota, suggesting a recent evolutionary innovation that highlights the evolvability of post-translational modifications of chromatin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.