ArticleAmerican journal of physiology. Heart and circulatory physiology2011
Improved functional vasodilation in obese Zucker rats following exercise training.
Article in American journal of physiology. Heart and circulatory physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Animal exercise studies in cardiovascular research: Current knowledge and optimal design-A position paper of the Committee on Cardiac Rehabilitation, Chinese Medical Doctors' Association.Journal of sport and health science · 2021Article
- Emerging Roles of Sympathetic Nerves and Inflammation in Perivascular Adipose Tissue.Cardiovascular drugs and therapy · 2019Review
- Chronic atorvastatin and exercise can partially reverse established skeletal muscle microvasculopathy in metabolic syndrome.American journal of physiology. Heart and circulatory physiology · 2018Article
- Beneficial Pleiotropic Antidepressive Effects of Cardiovascular Disease Risk Factor Interventions in the Metabolic Syndrome.Journal of the American Heart Association · 2018Article
- OBESITY AND CRITICAL ILLNESS: INSIGHTS FROM ANIMAL MODELS.Shock (Augusta, Ga.) · 2016Review
- Modulation of endothelial cell phenotype by physical activity: impact on obesity-related endothelial dysfunction.American journal of physiology. Heart and circulatory physiology · 2015Review
- Impaired vascular KATP function attenuates exercise capacity in obese zucker rats.Microcirculation (New York, N.Y. : 1994) · 2013Article
- Exercise training and cardiometabolic diseases: focus on the vascular system.Current hypertension reports · 2013 · on this mapReview
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
Obese individuals exhibit impaired functional vasodilation and exercise performance. We have demonstrated in obese Zucker rats (OZ), a model of morbid obesity, that insulin resistance impairs functional vasodilation via an increased thromboxane receptor (TP)-mediated vasoconstriction. Chronic treadmill exercise training improves functional vasodilation in the spinotrapezius muscle of the OZ, but the mechanisms responsible for the improvement in functional vasodilation are not clear. Based on evidence that exercise training improves insulin resistance, we hypothesized that, in the OZ, exercise training increases functional vasodilation and exercise capability due to decreases TP-mediated vasoconstriction associated with improved insulin sensitivity. Six-week-old lean Zucker rats (LZ) and OZ were exercised on a treadmill (24 m/min, 30 min/day, 5 days/wk) for 6 wk. An oral glucose tolerance test was performed at the end of the training period. We measured functional vasodilation in both exercise trained (spinotrapezius) and nonexercise trained (cremaster) muscles to determine whether the improved functional vasodilation following exercise training in OZ is due to a systemic improved insulin resistance. Compared with LZ, the sedentary OZ exhibited impairments in glucose tolerance and functional vasodilation in both muscles. The TP antagonist SQ-29548 improved the vasodilator responses in the sedentary OZ with no effect in the LZ. Exercising training of the LZ increased the functional vasodilation in spinotrapezius muscle, with no effect in the cremaster muscle. Exercising training of the OZ improved glucose tolerance, along with increased functional vasodilation, in both the spinotrapezius and cremaster muscles. SQ-29548 treatment had no effect on the vasodilator responses in either cremaster or spinotrapezius muscles of the exercise-trained OZ. These results suggest that, in the OZ, there is a global effect of exercising training to improve insulin resistance and increase functional vasodilation via a decreased TP-mediated vasoconstriction.
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