ArticleBioinformatics (Oxford, England)2011
Reconstruction of genealogical relationships with applications to Phase III of HapMap.
Article in Bioinformatics (Oxford, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- A Log-Ratio Biplot Approach for Exploring Genetic Relatedness Based on Identity by State.Frontiers in genetics · 2019Article
- Strategies for determining kinship in wild populations using genetic data.Ecology and evolution · 2016Review
- A Pipeline for Classifying Relationships Using Dense SNP/SNV Data and Putative Pedigree Information.Genetic epidemiology · 2016Article
- Parente2: a fast and accurate method for detecting identity by descent.Genome research · 2015Article
- PRIMUS: rapid reconstruction of pedigrees from genome-wide estimates of identity by descent.American journal of human genetics · 2014Article
- Historical pedigree reconstruction from extant populations using PArtitioning of RElatives (PREPARE).PLoS computational biology · 2014Article
- Identifying genetic relatives without compromising privacy.Genome research · 2014Article
- Identification of pedigree relationship from genome sharing.G3 (Bethesda, Md.) · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
motivationAccurate inference of genealogical relationships between pairs of individuals is paramount in association studies, forensics and evolutionary analyses of wildlife populations. Current methods for relationship inference consider only a small set of close relationships and have limited to no power to distinguish between relationships with the same number of meioses separating the individuals under consideration (e.g. aunt-niece versus niece-aunt or first cousins versus great aunt-niece).
resultsWe present CARROT (ClAssification of Relationships with ROTations), a novel framework for relationship inference that leverages linkage information to differentiate between rotated relationships, that is, between relationships with the same number of common ancestors and the same number of meioses separating the individuals under consideration. We demonstrate that CARROT clearly outperforms existing methods on simulated data. We also applied CARROT on four populations from Phase III of the HapMap Project and detected previously unreported pairs of third- and fourth-degree relatives. AVAILABILITY: Source code for CARROT is freely available at http://carrot.stanford.edu. CONTACT: sofiakp@stanford.edu.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.