ArticleAmerican journal of clinical pathology2011
Human papillomavirus (HPV) detection using in situ hybridization in histologic samples: correlations with cytologic changes and polymerase chain reaction HPV detection.
Article in American journal of clinical pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Human papilloma virus genotypes associated with non-cervical HPV positive cancer development in UK and Ireland cohorts: a systematic review.BMC infectious diseases · 2025Pooled it
- Cytology versus HPV testing for cervical cancer screening in the general population.The Cochrane database of systematic reviews · 2017Pooled it
- Detection of HPV DNA in Cervical Intraepithelial Neoplasia Using In Situ Hybridization.Journal of clinical medicine · 2026Article
- High-Risk HPV CISH Detection in Cervical Biopsies with Weak and/or Focal p16 Immunohistochemical Positivity.International journal of molecular sciences · 2024Article
- Human papillomavirus genotype distribution patterns in Zimbabwe; is the bivalent vaccine sufficient?Intervirology · 2024Review
- Novel computational and drug design strategies for inhibition of human papillomavirus-associated cervical cancer and DNA polymerase theta receptor by Apigenin derivatives.Scientific reports · 2023Article
- Detection of Human Papillomavirus in Squamous Lesions of the Conjunctiva Using RNA and DNA In-Situ Hybridization.International journal of molecular sciences · 2022Article
- Current and Emerging Molecular Tests for Human Papillomavirus-Related Neoplasia in the Genomic Era.The Journal of molecular diagnostics : JMD · 2017Review
- Human Papillomavirus Laboratory Testing: the Changing Paradigm.Clinical microbiology reviews · 2016Review
- Review
- Is real-time PCR the correct method to evaluate the incidence of human papillomavirus in prepuces of asymptomatic boys and men?World journal of urology · 2014Article
- An intelligent clinical decision support system for patient-specific predictions to improve cervical intraepithelial neoplasia detection.BioMed research international · 2014Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Although in situ hybridization (ISH) and polymerase chain reaction (PCR) have extensively been used on cytology specimens, there have been limited reports of the usefulness of these techniques in relation to confirmed histologic findings. In this study, we used PCR and ISH to detect human papillomavirus (HPV) in cytologic and histologic specimens, respectively. By using positive and negative likelihood ratios, we attempted to identify any predictive role of ISH testing alone or in combination with PCR for the development of high-grade histologic lesions (cervical intraepithelial neoplasia [CIN] 2+). In our study, ISH was a useful method for detection of HPV, even in a large fraction of samples with normal cytologic or biopsy findings. We suggest that when used together and evaluated in conjunction with histologic sections, ISH is a useful tool for ancillary molecular testing of HPV infection in cervical lesions, especially in CIN 2+ histological lesions where its analytic sensitivities and specificities were as good as those of PCR testing.
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Registered trials
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