ArticleHIV clinical trials
Cardiovagal autonomic function in HIV-infected patients with unsuppressed HIV viremia.
Article in HIV clinical trials. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A meta-analysis of HIV and heart rate variability in the era of antiretroviral therapy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2016Pooled it
- Ambulatory Blood Pressure Monitoring in Individuals with HIV: A Systematic Review and Meta-Analysis.PloS one · 2016Pooled it
- Relationship between inflammatory and coagulation biomarkers and cardiac autonomic function in HIV-infected individuals.Biomarkers in medicine · 2014Trial
- The Interplay of HIV and Long COVID in Sub-Saharan Africa: Mechanisms of Endothelial Dysfunction.Current cardiology reports · 2024Review
- Direct and indirect cardiovascular and cardiometabolic sequelae of the combined anti-retroviral therapy on people living with HIV.Frontiers in physiology · 2023Review
- Linear and non-linear analysis of heart rate variability in HIV-positive patients on two different antiretroviral therapy regimens.BMC infectious diseases · 2021Article
- HIV Infection and the Risk of World Health Organization-Defined Sudden Cardiac Death.Journal of the American Heart Association · 2021Observational
- Reduced functional connectivity between ventromedial prefrontal cortex and insula relates to longer corrected QT interval in HIV+ and HIV- individuals.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2017Article
- Untangling the Gordian knot of HIV, stress, and cognitive impairment.Neurobiology of stress · 2016Review
- The α7-nicotinic receptor is upregulated in immune cells from HIV-seropositive women: consequences to the cholinergic anti-inflammatory response.Clinical & translational immunology · 2015Article
- Mechanisms Influencing Circadian Blood Pressure Patterns Among Individuals with HIV.Current hypertension reports · 2015Review
- Autonomic Function is Associated with Fitness Level in HIV-Infected Individuals.Jacobs journal of AIDS/HIV · 2015Article
- HIV-1-Tat excites cardiac parasympathetic neurons of nucleus ambiguus and triggers prolonged bradycardia in conscious rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Rates of autonomic dysfunction in HIV patients receiving antiretroviral therapy.Journal of neurovirology · 2013Article
- Autonomic dysfunction is common in HIV and associated with distal symmetric polyneuropathy.Journal of neurovirology · 2013Article
- Effects of antiretroviral therapy on autonomic function in early HIV infection: a preliminary report.International journal of medical sciences · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
purposeHIV infection has been implicated in dysregulation of the autonomic nervous system.
methodCross-sectional study examining the relationship between the presence of persistent detectable HIV viral load with autonomic function, measured by heart rate variability (HRV). Non-virologic suppression (NVS) was defined as having a detectable viral load for at least 3 months prior to autonomic function testing. HRV was measured during the following 4 maneuvers: resting and paced respirations and sustained handgrip and tilt. Inferences on parasympathetic and sympathetic modulations were determined by analyzing time and frequency domains of HRV.
results57 participants were enrolled in 3 groups: 22 were HIV-infected participants with HIV virologic suppression (VS; undetectable HIV viral load), 9 were HIV-infected participants who had NVS, and 26 were HIV seronegative controls. There were lower time domain parameters in the HIV-infected group as a whole compared to controls. There were no significant differences in time domain parameters among HIV-infected participants. There were no differences in frequency domain parameters during any of the maneuvers between controls and all HIV-infected participants, nor between the NVS and VS groups.
conclusionThere were differences in autonomic function between HIV-infected individuals and HIV seronegative controls, but not between the NVS and VS groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.