ArticleBiomaterials2011
Anisotropic material synthesis by capillary flow in a fluid stripe.
Article in Biomaterials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications.Military Medical Research · 2023Review
- Fabrication and desired properties of conductive hydrogel dressings for wound healing.RSC advances · 2023Review
- Review
- Functional Hydrogels for Treatment of Chronic Wounds.Gels (Basel, Switzerland) · 2022Review
- Engineering calcium peroxide based oxygen generating scaffolds for tissue survival.Biomaterials science · 2021Article
- Mineralization of Biomaterials for Bone Tissue Engineering.Bioengineering (Basel, Switzerland) · 2020Review
- Synthesis and characterization of photocrosslinkable hydrogels from bovine skin gelatin.RSC advances · 2019Article
- A simple layer-stacking technique to generate biomolecular and mechanical gradients in photocrosslinkable hydrogels.Biofabrication · 2019Article
- Spatially and Temporally Controlled Hydrogels for Tissue Engineering.Materials science & engineering. R, Reports : a review journal · 2017Article
- Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels.Biomaterials · 2015Review
- Hydrogel Templates for Rapid Manufacturing of Bioactive Fibers and 3D Constructs.Advanced healthcare materials · 2015Article
- A Current View of Functional Biomaterials for Wound Care, Molecular and Cellular Therapies.BioMed research international · 2015Review
- Hybrid hydrogels containing vertically aligned carbon nanotubes with anisotropic electrical conductivity for muscle myofiber fabrication.Scientific reports · 2014Article
- 25th anniversary article: Rational design and applications of hydrogels in regenerative medicine.Advanced materials (Deerfield Beach, Fla.) · 2014Review
- Multi-gradient hydrogels produced layer by layer with capillary flow and crosslinking in open microchannels.Lab on a chip · 2012Article
- Designer hydrophilic regions regulate droplet shape for controlled surface patterning and 3D microgel synthesis.Small (Weinheim an der Bergstrasse, Germany) · 2012Article
- Biomimetic tissues on a chip for drug discovery.Drug discovery today · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
We present a simple bench-top technique to produce centimeter long concentration gradients in biomaterials incorporating soluble, material, and particle gradients. By patterning hydrophilic regions on a substrate, a stripe of prepolymer solution is held in place on a glass slide by a hydrophobic boundary. Adding a droplet to one end of this "pre-wet" stripe causes a rapid capillary flow that spreads the droplet along the stripe to generate a gradient in the relative concentrations of the droplet and pre-wet solutions. The gradient length and shape are controlled by the pre-wet and droplet volumes, stripe thickness, fluid viscosity and surface tension. Gradient biomaterials are produced by crosslinking gradients of prepolymer solutions. Demonstrated examples include a concentration gradient of cells encapsulated in three dimensions (3D) within a homogeneous biopolymer and a constant concentration of cells encapsulated in 3D within a biomaterial gradient exhibiting a gradient in cell spreading. The technique employs coated glass slides that may be purchased or custom made from tape and hydrophobic spray. The approach is accessible to virtually any researcher or student and should dramatically reduce the time required to synthesize a wide range of gradient biomaterials. Moreover, since the technique employs passive mechanisms it is ideal for remote or resource poor settings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.