Evidence map›Paper›PMID 21684471›Full record

ReviewCurrent problems in pediatric and adolescent health care2011

Fetal origins of adult disease.

Kara Calkins, Sherin U Devaskar

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current problems in pediatric and adolescent health care, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 297 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
297citing papers in PubMed, 8 pooled it
38.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02786420 completednot on this mapstarted 2015, after this paper: background citation

Imaging Innovations for Placental Assessment in Response to Environmental Pollution

TypeobservationalSponsorUniversity of California, Los AngelesRan2015 to 2020Enrolled199ConditionsPlacental Disease
NCT05780047 nacompletednot on this mapstarted 2022, after this paper: background citation

Personalized Mobile Intervention to Reduce Exposure to Endocrine Disrupting Chemicals (EDCs) in Women of Child-Bearing Age and Their Partners

TypeinterventionalSponsorMillion Marker Wellness, Inc.Ran2022 to 2022Enrolled434ConditionsEndocrine Disrupting Chemicals, Environmental Exposure, Health Literacy, Bisphenol AArmsMail-in Urine Test for EDCs
3 · Its place in the literature

Who cites it

297 citing papers in PubMed, 8 syntheses or guidelines pooled it, 634 citations in OpenAlex.

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  4. Research Review: Developmental origins of depression - a systematic review and meta-analysis.Journal of child psychology and psychiatry, and allied disciplines · 2021
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237 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kara CalkinsDepartment of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Sherin U Devaskar
University of California, Los Angeles · US

Funding

Prenatal Metabolic Programming of the OffspringR01HD041230 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEVASKAR, SHERIN U · 2001 to 2019
$5.2M
Building Interdisciplinary Research Careers in Women's Health (BIRCWH) CenterK12HD001400 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHAUDHURI, GAUTAM · 2000 to 2009
$4.2M
POSTNATAL ASPECTS OF A GLUCOSE TRANSPORTERR01HD033997 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEVASKAR, SHERIN U · 1995 to 2008
$3.1M
PERINATAL METABOLIC AND HORMONAL EFFECTSR01HD025024 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEVASKAR, SHERIN U · 1996 to 2010
$2.6M
Role of Placental Transport In Fetal GrowthR01HD046979 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEVASKAR, SHERIN U · 2004 to 2008
$1.7M
DEVELOPMENTAL REGULATION OF NEURON INSULIN-LIKE PEPTIDER29HD025024 · NICHD · SAINT LOUIS UNIVERSITY · PI DEVASKAR, SHERIN U. · 1989 to 1993
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NICHD NIH HHS HD-046979NICHD NIH HHS HD25024NICHD NIH HHS HD-33997NICHD NIH HHS HD-41230NICHD NIH HHS K12HD00140NICHD NIH HHS K12 HD001400NICHD NIH HHS R01 HD025024NICHD NIH HHS R01 HD033997NICHD NIH HHS R01 HD046979
6 · The paper itself

Abstract

Dr. David Barker first popularized the concept of fetal origins of adult disease (FOAD). Since its inception, FOAD has received considerable attention. The FOAD hypothesis holds that events during early development have a profound impact on one's risk for development of future adult disease. Low birth weight, a surrogate marker of poor fetal growth and nutrition, is linked to coronary artery disease, hypertension, obesity, and insulin resistance. Clues originally arose from large 20th century, European birth registries. Today, large, diverse human cohorts and various animal models have extensively replicated these original observations. This review focuses on the pathogenesis related to FOAD and examines Dr. David Barker's landmark studies, along with additional human and animal model data. Implications of the FOAD extend beyond the low birth weight population and include babies exposed to stress, both nutritional and nonnutritional, during different critical periods of development, which ultimately result in a disease state. By understanding FOAD, health care professionals and policy makers will make this issue a high health care priority and implement preventive measures and treatment for those at higher risk for chronic diseases.

Indexed as

Chronic DiseaseEpigenomicsFemaleFetal DevelopmentGenetic Predisposition to DiseaseHumansInfant, Low Birth WeightInfant, NewbornMalePregnancyPrenatal Exposure Delayed EffectsRisk Factors

Identifiers

PMID21684471
PMCPMC4608552
OpenAlexW2070872186

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.