Evidence map›Paper›PMID 21684347›Full record

ReviewMicrobes and infection2011

Cryptococcus gattii: an emerging fungal pathogen infecting humans and animals.

Edmond J Byrnes, Karen H Bartlett, John R Perfect, Joseph Heitman

Abstract readReview
In one paragraph

Review in Microbes and infection, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 153 citations in OpenAlex.

  1. Review
  2. An Emerging Infectious Yeast to Watch:Journal of fungi (Basel, Switzerland) · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Blap-6, a Novel Antifungal Peptide from the Chinese Medicinal BeetleInternational journal of molecular sciences · 2024
    Article
  7. Article
  8. Models for Inducing Experimental Cryptococcosis in Mice.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Frontiers in cellular and infection microbiology · 2022
    Article
  15. Article
  16. Environmental Status ofJournal of fungi (Basel, Switzerland) · 2021
    Review
  17. Article
  18. Small-molecule inhibitors for the Prp8 intein as antifungal agents.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  19. Review
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Edmond J ByrnesDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.
Karen H Bartlett
John R Perfect
Joseph Heitman
Duke Medical Center · USUniversity of British Columbia · CA

Funding

Structure, function, and evolution of the Cryptococcus MAT locusR01AI050113 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2002 to 2024
$8.5M
ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITINGR01AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 1997 to 2025
$6.7M
Genetics of Cryptococcus sexual reproductionR37AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2011 to 2020
$4.9M
Pathobiology of C. neoformans in the Central Nervous SystemR01AI073896 · NIAID · DUKE UNIVERSITY · PI PERFECT, JOHN R. · 2008 to 2018
$4.4M
NIAID NIH HHS R01 AI039115NIAID NIH HHS R01 AI050113NIAID NIH HHS R01 AI073896NIAID NIH HHS R01 AI50113NIAID NIH HHS R01 AI73896NIAID NIH HHS R37 AI039115NIAID NIH HHS R37 AI39115
6 · The paper itself

Abstract

Infectious fungi are among a broad group of microbial pathogens that has and continues to emerge concomitantly due to the global AIDS pandemic as well as an overall increase of patients with compromised immune systems. In addition, many pathogens have been emerging and re-emerging, causing disease in both individuals who have an identifiable immune defect and those who do not. The fungal pathogen Cryptococcus gattii can infect individuals with and without an identifiable immune defect, with a broad geographic range including both endemic areas and emerging outbreak regions. Infections in patients and animals can be severe and often fatal if untreated. We review the molecular epidemiology, population structure, clinical manifestations, and ecological niche of this emerging pathogen.

Indexed as

AnimalsCommunicable Diseases, EmergingCryptococcosisCryptococcus gattiiDisease OutbreaksEndemic DiseasesHumansImmunocompromised HostMolecular Epidemiology

Identifiers

PMID21684347
PMCPMC3318971
OpenAlexW2019228137

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.