ReviewBiochemical pharmacology2011
Functional brain imaging of nicotinic effects on higher cognitive processes.
Review in Biochemical pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Chronic cigarette smoking is linked with structural alterations in brain regions showing acute nicotinic drug-induced functional modulations.Behavioral and brain functions : BBF · 2016Pooled it
- Neurobiological impact of nicotinic acetylcholine receptor agonists: an activation likelihood estimation meta-analysis of pharmacologic neuroimaging studies.Biological psychiatry · 2015Pooled it
- An exploratory, randomised, crossover study to investigate the effect of nicotine on cognitive function in healthy adult smokers who use an electronic cigarette after a period of smoking abstinence.Harm reduction journal · 2024Trial
- CDP-choline and galantamine, a personalized α7 nicotinic acetylcholine receptor targeted treatment for the modulation of speech MMN indexed deviance detection in healthy volunteers: a pilot study.Psychopharmacology · 2020Trial
- Attention-enhancing effects of propranolol and synergistic effects with nicotine.Cognitive, affective & behavioral neuroscience · 2020Trial
- Effects of nicotine on smooth pursuit eye movements in healthy non-smokers.Psychopharmacology · 2019Trial
- Effects of nicotine on response inhibition and interference control.Psychopharmacology · 2017Trial
- Nicotine restores functional connectivity of the ventral attention network in schizophrenia.Neuropharmacology · 2016Trial
- Neuronal effects of nicotine during auditory selective attention in schizophrenia.Human brain mapping · 2016Trial
- COMT polymorphism modulates the resting-state EEG alpha oscillatory response to acute nicotine in male non-smokers.Genes, brain, and behavior · 2015Trial
- Neuronal effects of nicotine during auditory selective attention.Psychopharmacology · 2015Trial
- Effects of nicotine on social cognition, social competence and self-reported stress in schizophrenia patients and healthy controls.European archives of psychiatry and clinical neuroscience · 2013Trial
- Effects of risperidone, amisulpride and nicotine on eye movement control and their modulation by schizotypy.Psychopharmacology · 2013Trial
- The Basal Forebrain Cholinergic Nuclei and Their Relevance to Schizophrenia and Other Psychotic Disorders.Frontiers in psychiatry · 2022Review
- APOE genotype influences P3b amplitude and response to smoking abstinence in young adults.Psychopharmacology · 2021Article
- Nicotinic receptor modulation of the default mode network.Psychopharmacology · 2021Article
- Evidence for positive allosteric modulation of cognitive-enhancing effects of nicotine by low-dose galantamine in rats.Pharmacology, biochemistry, and behavior · 2020Article
- Non-pharmacological factors that determine drug use and addiction.Neuroscience and biobehavioral reviews · 2020Review
- Evidence for positive allosteric modulation of cognitive-enhancing effects of nicotine in healthy human subjects.Psychopharmacology · 2020Article
- Nicotine and networks: Potential for enhancement of mood and cognition in late-life depression.Neuroscience and biobehavioral reviews · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Significant advances in human functional brain imaging offer new opportunities for direct observation of the effects of nicotine, novel nicotinic agonists and nicotinic antagonists on human cognitive and behavioral performance. Careful research over the last decade has enabled investigators to explore the role of nicotinic systems on the functional neuroanatomy and neural circuitry of cognitive tasks in domains such as selective attention, working memory, episodic memory, cognitive control, and emotional processing. In addition, recent progress in understanding functional connectivity between brain regions utilized during cognitive and emotional processes offers new opportunities for examining drug effects on network-related activity. This review will critically summarize available nicotinic functional brain imaging studies focusing on the specific cognitive domains of attention, memory, behavioral control, and emotional processing. Generally speaking, nicotine appears to increase task-related activity in non-smokers and deprived smokers, but not active smokers. By contrast, nicotine or nicotinic stimulation decreases the activity of structures associated with the default mode network. These particular patterns of activation and/or deactivation may be useful for early drug development and may be an efficient and cost-effective method of screening potential nicotinic agents. Further studies will have to be done to clarify whether such activity changes correlate with cognitive or affective outcomes that are clinically relevant. The use of functional brain imaging will be a key tool for probing pathologic changes related to brain illness and for nicotinic drug development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.