ArticleThe American journal of medicine2011
Elevated natriuretic peptide levels and cognitive function in community-dwelling older adults.
Article in The American journal of medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Association Between Cardiac Natriuretic Peptides and Lipid Profile: a Systematic Review and Meta-Analysis.Scientific reports · 2019Pooled it
- Neurocognitive function and CNS integrity in adult survivors of childhood hodgkin lymphoma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012Trial
- Proteomics signatures associated with cognitive trajectories: evidence from the English Longitudinal Study of Ageing.medRxiv : the preprint server for health sciences · 2026Article
- Heart-Brain Axis: Subclinical Cardiovascular Changes and Brain Health.Journal of the American Heart Association · 2026Review
- Predictive model of neurocognitive functioning after acute coronary syndrome. A machine learning approach.Journal of cardiovascular and thoracic research · 2025Article
- Association of household chemicals use with cognitive function among Chinese older adults.Heliyon · 2024Article
- Prevalence and factors associated with cognitive impairment in Chinese heart failure patients: A pilot study.Frontiers in cardiovascular medicine · 2022Article
- Cognitive Dysfunction after Heart Disease: A Manifestation of the Heart-Brain Axis.Oxidative medicine and cellular longevity · 2021Review
- Fine Particulate Matter and Poor Cognitive Function among Chinese Older Adults: Evidence from a Community-Based, 12-Year Prospective Cohort Study.Environmental health perspectives · 2020Article
- Change in NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) Level and Risk of Dementia in Multi-Ethnic Study of Atherosclerosis (MESA).Hypertension (Dallas, Tex. : 1979) · 2020Observational
- Clinical and Biological Correlates of Preoperative Cognitive Functioning of Glioma and Meningioma Patients.BioMed research international · 2020Article
- High-Sensitive Troponin T, Natriuretic Peptide, and Cognitive Change.Journal of the American Geriatrics Society · 2019Article
- Article
- Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.Cellular signalling · 2018Review
- N-Terminal pro-Brain Natriuretic Peptide and Associations With Brain Magnetic Resonance Imaging (MRI) Features in Middle Age: The CARDIA Brain MRI Study.Frontiers in neurology · 2018Article
- [Methylphenidate in a patient with Alzheimer's disease : Increase in drive and cardiac performance].Zeitschrift fur Gerontologie und Geriatrie · 2017Article
- Association Between Subclinical Cardiac Biomarkers and Clinically Manifest Cardiac Diseases With Cortical Cerebral Microinfarcts.JAMA neurology · 2017Article
- Cognitive decline in heart failure.Heart failure reviews · 2016Review
- N-terminal pro-brain natriuretic peptide and abnormal brain aging: The AGES-Reykjavik Study.Neurology · 2015Article
- Correlation between B-Type Natriuretic Peptide and Functional/Cognitive Parameters in Discharged Congestive Heart Failure Patients.International journal of endocrinology · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNatriuretic peptides have prognostic value across a wide spectrum of cardiovascular diseases and may predict cognitive dysfunction in patients with cardiovascular disease, even in the absence of previous stroke. Little is known about the association of natriuretic peptides with cognitive function in community-dwelling adults. We assessed the association between N-terminal pro B-type natriuretic peptide (NT-proBNP) levels and cognitive function in community-dwelling ambulatory older adults in the Rancho Bernardo Study.
methodsWe studied 950 men and women, aged 60 years and older, who attended a research clinic visit where a medical history and examination were performed, and blood for cardiovascular disease risk factors and NT-proBNP levels were obtained. Three cognitive function tests were administered: the Mini Mental State Examination (MMSE), Trail-Making Test B (Trails B), and Category Fluency.
resultsParticipants with high NT-proBNP levels (≥450 pg/mL; n=198) were older and had a higher prevalence of coronary heart disease (12% vs 30%), and stroke (5% vs 11%; P≤.001 for both). In unadjusted analyses, all 3 cognitive function test scores were significantly associated with NT-proBNP levels (P<.001). After adjusting for age, sex, education, hypertension, body mass index, exercise, alcohol use, smoking, low density lipoprotein cholesterol, creatinine clearance, and previous cardiovascular disease, elevated NT-proBNP levels remained independently associated with poor cognitive performance on MMSE (odds ratio [OR] 2.0; 95% confidence interval [CI], 1.1-3.6; P=.02) and Trails B (OR 1.7; 95% CI, 1.2-2.7; P=.01), but not Category Fluency (OR 1.4; 95% CI, 0.9-2.2; P=.19). Results were unchanged after excluding the 6% of participants with a history of stroke.
conclusionsNT-proBNP levels were strongly and independently associated with poor cognitive function in community-dwelling older adults.
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