ReviewFree radical biology & medicine2011
Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy.
Review in Free radical biology & medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- The multifaceted role of mitochondria in autism spectrum disorder.Molecular psychiatry · 2025Review
- The chemical biology of dinitrogen trioxide.Redox biochemistry and chemistry · 2024Article
- Mutations associated with autism lead to similar synaptic and behavioral alterations in both sexes of male and female mouse brain.Scientific reports · 2024Article
- Hypoxia-inducible factors and essential hypertension: narrative review of experimental and clinical data.Pharmacological reports : PR · 2023Review
- Cell physiology and molecular mechanism of anion transport by erythrocyte band 3/AE1.American journal of physiology. Cell physiology · 2021Review
- Biological Mechanisms ofAntioxidants (Basel, Switzerland) · 2021Review
- Nitrite elicits divergent NO-dependent signaling that associates with outcome in out of hospital cardiac arrest.Redox biology · 2020Article
- Nitrate partially inhibits lipopolysaccharide-induced inflammation by maintaining mitochondrial function.The Journal of international medical research · 2020Article
- Astaxanthin Ameliorates Ischemic-Hypoxic-Induced Neurotrophin Receptor p75 Upregulation in the Endothelial Cells of Neonatal Mouse Brains.International journal of molecular sciences · 2019Article
- Nitrite and nitrate chemical biology and signalling.British journal of pharmacology · 2019Review
- Cerebral ischemia and neuroregeneration.Neural regeneration research · 2018Review
- The Ability of Nitric Oxide to Lower Intraocular Pressure Is Dependent on Guanylyl Cyclase.Investigative ophthalmology & visual science · 2017Article
- Re-evaluation of sodium nitrate (E 251) and potassium nitrate (E 252) as food additives.EFSA journal. European Food Safety Authority · 2017Article
- Re-evaluation of potassium nitrite (E 249) and sodium nitrite (E 250) as food additives.EFSA journal. European Food Safety Authority · 2017Article
- A new paradigm for XOR-catalyzed reactive species generation in the endothelium.Pharmacological reports : PR · 2015Review
- Convergence of biological nitration and nitrosation via symmetrical nitrous anhydride.Nature chemical biology · 2015Article
- Nitrite therapy improves survival postexposure to chlorine gas.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Regulation of obesity and insulin resistance by nitric oxide.Free radical biology & medicine · 2014Review
- Xanthine oxidoreductase-catalyzed reduction of nitrite to nitric oxide: insights regarding where, when and how.Nitric oxide : biology and chemistry · 2013Review
- Effects of erythrocyte aging on nitric oxide and nitrite metabolism.Antioxidants & redox signaling · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Beyond an inert oxidation product of nitric oxide (NO) metabolism, current thinking posits a key role for nitrite as a mediator of NO signaling, especially during hypoxia. This concept has been discussed in the context of nitrite serving a role as an endogenous modulator of NO homeostasis, but also from a novel clinical perspective whereby nitrite therapy may replenish NO signaling and prevent ischemic tissue injury. Indeed, the relatively rapid translation of studies delineating mechanisms of action to ongoing and planned clinical trials has been critical in fuelling interest in nitrite biology, and several excellent reviews have been written on this topic. In this article we limit our discussions to current concepts and what we feel are questions that remain unanswered within the paradigm of nitrite being a mediator of NO biology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.