ArticleGastroenterology2011
Differential, type I interferon-mediated autophagic trafficking of hepatitis C virus proteins in mouse liver.
Article in Gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Review
- Autophagy, Unfolded Protein Response, and Neuropilin-1 Cross-Talk in SARS-CoV-2 Infection: What Can Be Learned from Other Coronaviruses.International journal of molecular sciences · 2021Review
- Crosstalk between Autophagy and Type I Interferon Responses in Innate Antiviral Immunity.Viruses · 2019Review
- Diverse Functions of Autophagy in Liver Physiology and Liver Diseases.International journal of molecular sciences · 2019Review
- Subversion of cellular autophagy during virus infection: Insights from hepatitis B and hepatitis C viruses.Liver research (Beijing, China) · 2018Article
- Autophagy: The multi-purpose bridge in viral infections and host cells.Reviews in medical virology · 2018Review
- Differential Effects of Autophagy-Related 10 Protein on HCV Replication and Autophagy Flux Are Mediated by Its CysteineFrontiers in immunology · 2018Article
- Review
- Contribution of autophagy to antiviral immunity.FEBS letters · 2015Review
- Hepatitis C virus and autophagy.Biological chemistry · 2015Review
- The role of autophagy in microbial infection and immunity.ImmunoTargets and therapy · 2015Review
- Autophagy in HCV infection: keeping fat and inflammation at bay.BioMed research international · 2014Review
- Functions of autophagy in normal and diseased liver.Autophagy · 2013Review
- Suppression of autophagy enhanced growth inhibition and apoptosis of interferon-β in human glioma cells.Molecular neurobiology · 2013Article
- Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Pathogen-induced autophagy signaling in innate immunity.Journal of innate immunity · 2013Review
- Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence.Drug design, development and therapy · 2013Article
- Targeting autophagy for the treatment of liver diseases.Pharmacological research · 2012Review
- Living in the liver: hepatic infections.Nature reviews. Immunology · 2012Review
- IFN-α/β and autophagy: tug-of-war between HCV and the host.Autophagy · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND &
aimsThe hepatitis C virus (HCV) serine protease NS3/4A can cleave mitochondria-associated antiviral signaling protein (MAVS) and block retinoic acid-inducible gene I-mediated interferon (IFN) responses. Although this mechanism is thought to have an important role in HCV-mediated innate immunosuppression, its significance in viral persistence is not clear.
methodsWe generated transgenic mice that express the HCV NS3/4A proteins specifically in the liver and challenged the animals with a recombinant vesicular stomatitis virus, a synthetic HCV genome, IFN alfa, or IFN beta. We evaluated the effects of HCV serine protease on the innate immune responses and their interactions.
resultsExpression of HCV NS3/4A resulted in cleavage of intrahepatic MAVS; challenge of transgenic mice with vesicular stomatitis virus or a synthetic HCV genome induced strong, type I IFN-mediated responses that were not significantly lower than those of control mice. Different challenge agents induced production of different ratios of IFN alfa and beta, resulting in different autophagic responses and vesicular trafficking patterns of endoplasmic reticulum- and mitochondria-associated viral proteins. IFN beta promoted degradation of the viral proteins by the autolysosome. Variant isoforms of MAVS were associated with distinct, type I IFN-mediated autophagic responses; these responses have a role in trafficking of viral components to endosomal compartments that contain Toll-like receptor-3.
conclusionsIFN beta mediates a distinct autophagic mechanism of antiviral host defense. MAVS has an important role in type I IFN-induced autophagic trafficking of viral proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.