ArticleDevelopmental biology2011
Growth of limb muscle is dependent on skeletal-derived Indian hedgehog.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Pamidronate attenuates muscle loss after pediatric burn injury.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Trial
- The role of bone-derived factors in bone and muscle communication.Frontiers in endocrinology · 2025Review
- Bulk and single-cell alternative splicing analyses reveal roles of TRA2B in myogenic differentiation.Cell proliferation · 2024Article
- Association analysis of transcriptome and quasi-targeted metabolomics reveals the regulation mechanism underlying broiler muscle tissue development at different levels of dietary guanidinoacetic acid.Frontiers in veterinary science · 2024Article
- Causal relationship between sarcopenia and osteoarthritis: a bi-directional two-sample mendelian randomized study.European journal of medical research · 2023Article
- Targeting the Hedgehog Pathway in Rhabdomyosarcoma.Cancers · 2023Review
- Article
- Review
- Article
- The Regulation of Growth in Developing, Homeostatic, and Regenerating Tetrapod Limbs: A Minireview.Frontiers in cell and developmental biology · 2021Review
- Advances in cancer cachexia: Intersection between affected organs, mediators, and pharmacological interventions.Biochimica et biophysica acta. Reviews on cancer · 2020Review
- An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice.eLife · 2019Article
- Expression profile analysis of long non-coding RNA in skeletal muscle of osteoporosis by microarray and bioinformatics.Journal of biological engineering · 2019Article
- Bone Pain and Muscle Weakness in Cancer Patients.Current osteoporosis reports · 2017Review
- Non-myogenic Contribution to Muscle Development and Homeostasis: The Role of Connective Tissues.Frontiers in cell and developmental biology · 2017Review
- Review
- Deletion of connexin43 in osteoblasts/osteocytes leads to impaired muscle formation in mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Cancer-associated muscle weakness: What's bone got to do with it?BoneKEy reports · 2015Review
- Molecular mechanisms of bone metastasis and associated muscle weakness.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014Review
- Forum on bone and skeletal muscle interactions: summary of the proceedings of an ASBMR workshop.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
During embryogenesis, muscle and bone develop in close temporal and spatial proximity. We show that Indian Hedgehog, a bone-derived signaling molecule, participates in growth of skeletal muscle. In Ihh(-/-) embryos, skeletal muscle development appears abnormal at embryonic day 14.5 and at later ages through embryonic day 20.5, dramatic losses of hindlimb muscle occur. To further examine the role of Ihh in myogenesis, we manipulated Ihh expression in the developing chick hindlimb. Reduction of Ihh in chicken embryo hindlimbs reduced skeletal muscle mass similar to that seen in Ihh(-/-) mouse embryos. The reduction in muscle mass appears to be a direct effect of Ihh since ectopic expression of Ihh by RCAS retroviral infection of chicken embryo hindlimbs restores muscle mass. These effects are independent of bone length, and occur when Shh is not expressed, suggesting Ihh acts directly on fetal myoblasts to regulate secondary myogenesis. Loss of muscle mass in Ihh null mouse embryos is accompanied by a dramatic increase in myoblast apoptosis by a loss of p21 protein. Our data suggest that Ihh promotes fetal myoblast survival during their differentiation into secondary myofibers by maintaining p21 protein levels.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.