ArticleNeurobiology of aging2012
Perimenopausal regulation of steroidogenesis in the nonhuman primate.
Article in Neurobiology of aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate in Alzheimer's Disease: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2019Pooled it
- The aged female rhesus macaque as a translational model for human menopause and hormone therapy.Hormones and behavior · 2024Article
- Age-related increase in the expression of 11β-hydroxysteroid dehydrogenase type 1 in the hippocampus of male rhesus macaques.Frontiers in aging neuroscience · 2024Article
- Effect of estradiol replacement on hippocampal concentrations of estrogens in aged rhesus macaques maintained on an obesogenic diet.Biochemistry and biophysics reports · 2023Article
- Longitudinal evaluation of dehydroepiandrosterone (DHEA), its sulfated form and estradiol with cancer-related cognitive impairment in early-stage breast cancer patients receiving chemotherapy.Scientific reports · 2022Article
- Brain-derived estrogen and neural function.Neuroscience and biobehavioral reviews · 2022Review
- Lack of effect of short-term DHEA supplementation on the perimenopausal ovary†.Biology of reproduction · 2020Article
- Beyond Glucocorticoids: Integrating Dehydroepiandrosterone (DHEA) into Animal Welfare Research.Animals : an open access journal from MDPI · 2020Review
- Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders.Frontiers in endocrinology · 2019Review
- Effect of short-term DHEA supplementation on serum and hippocampal estrogen concentrations in perimenopausal female rhesus macaques.Neurobiology of aging · 2017Article
- Effect of caloric restriction on plasma melatonin levels in aged rhesus macaques.Neurobiology of aging · 2017Article
- Effect of androgen supplementation on 24-hour activity-rest patterns of aged male rhesus macaques.Neurobiology of aging · 2017Article
- Cognition in aged rhesus monkeys: effect of DHEA and correlation with steroidogenic gene expression.Genes, brain, and behavior · 2017Article
- Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair.Frontiers in aging neuroscience · 2017Article
- Aging-induced changes in sex-steroidogenic enzymes and sex-steroid receptors in the cortex, hypothalamus and cerebellum.The journal of physiological sciences : JPS · 2015Article
- Selective targeting of GnRH-II neurons to block ovulation.Contraception · 2015Article
- Effects of Age and Estradiol on Gene Expression in the Rhesus Macaque Hypothalamus.Neuroendocrinology · 2015Article
- Allopregnanolone as a mediator of affective switching in reproductive mood disorders.Psychopharmacology · 2014Review
- Androgen supplementation during aging: development of a physiologically appropriate protocol.Rejuvenation research · 2014Article
- Testosterone increases circulating dehydroepiandrosterone sulfate levels in the male rhesus macaque.Frontiers in endocrinology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Human aging is characterized by a marked decrease in circulating levels of dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS), hormonal changes associated with cognitive decline. Despite beneficial effects of DHEA supplementation in rodents, studies in elderly humans have generally failed to show cognitive improvement after treatment. In the present study we evaluate the effects of age and estradiol supplementation on expression of genes involved in the de novo synthesis of DHEA and its conversion to estradiol in the rhesus macaque hippocampus. Using reverse transcription polymerase chain reaction (RT-PCR) we demonstrate the expression of genes associated with this synthesis in several areas of the rhesus brain. Furthermore, real-time PCR reveals an age-related attenuation of hippocampal expression level of the genes CYP17A1, STS, and 3BHSD1/2. Additionally, short-term administration of estradiol is associated with decreased expression of CYP17A1, STS, SULT2B1, and AROMATASE, consistent with a downregulation not only of estrogen synthesis from circulating DHEA, but also of de novo DHEA synthesis within the hippocampus. These findings suggest a decline in neurosteroidogenesis may account for the inefficacy of DHEA supplementation in elderly humans, and that central steroidogenesis may be a function of circulating hormones and menopausal status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.