ArticleThe Journal of allergy and clinical immunology2011
Adaptive cytokine production in early life differentially predicts total IgE levels and asthma through age 5 years.
Article in The Journal of allergy and clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.The Journal of allergy and clinical immunology · 2013Pooled it
- Early oral immunotherapy in peanut-allergic preschool children is safe and highly effective.The Journal of allergy and clinical immunology · 2017Trial
- Cough during infancy and subsequent childhood asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Trial
- Umbilical Cord Blood Biomarkers for Early Risk Stratification of Childhood Asthma and Atopic Dermatitis: A Developmental and Critical Appraisal.Journal of asthma and allergy · 2026Review
- Early origins of lung disease: towards an interdisciplinary approach.European respiratory review : an official journal of the European Respiratory Society · 2020Review
- Laser Light Therapy in Inflammatory, Musculoskeletal, and Autoimmune Disease.Current allergy and asthma reports · 2019Review
- Maternal Cytokine Profiles during Pregnancy Predict Asthma in Children of Mothers without Asthma.American journal of respiratory cell and molecular biology · 2018Article
- Inception of early-life allergen-induced airway hyperresponsiveness is reliant on IL-13Science immunology · 2018Article
- Caesarean Section is associated with reduced perinatal cytokine response, increased risk of bacterial colonization in the airway, and infantile wheezing.Scientific reports · 2017Article
- Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers.The Journal of allergy and clinical immunology · 2017Article
- Article
- Exploration of early-life candidate biomarkers for childhood asthma using antibody arrays.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2016Article
- Epigenetics in allergic diseases.Current opinion in pediatrics · 2015Review
- Early predictors of asthma and allergy in children: the role of epigenetics.Current opinion in allergy and clinical immunology · 2015Review
- Differentiating asthma phenotypes in young adults through polyclonal cytokine profiles.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2014Article
- Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop.The Journal of allergy and clinical immunology · 2014Article
- Effect of low-level laser therapy on allergic asthma in rats.Lasers in medical science · 2014Article
- Atopy, cytokine production, and airway reactivity as predictors of pre-school asthma and airway responsiveness.Pediatric pulmonology · 2014Article
- Detection of immunoglobulin isotypes from dried blood spots.Journal of immunological methods · 2014Article
- Perinatal tumor necrosis factor-α production, influenced by maternal pregnancy weight gain, predicts childhood asthma.American journal of respiratory and critical care medicine · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAlthough it has been postulated that allergic disease is associated with a predominance of T(H)2 cells, whether IgE levels and asthma might differ in their relation to early-life cytokine production is not known.
objectiveWe sought to assess the relationship between first-year adaptive immune cytokine production with asthma and total IgE levels through age 5 years in a nonselected birth cohort.
methodsMitogen (concanavalin A/phorbol 12-myristate 13-acetate)-stimulated IL-4, IL-5, IL-13, and IFN-γ levels were measured in supernatants from cord blood mononuclear cells and PBMCs at birth, 3 months, and 12 months. Total serum IgE levels and physician-diagnosed active asthma were assessed at 1, 2, 3, and 5 years. Longitudinal models that adjust for both T(H)1 and T(H)2 cytokine production were used to determine relations of outcomes.
resultsRelations of cytokines to total IgE levels and asthma were strikingly different. Total IgE levels through age 5 years were positively associated with 12-month IL-4 (P < .001), IL-5 (P < .001), and IL-13 (P = .02) levels when adjusted for IFN-γ levels and inversely associated with 12-month IFN-γ levels after IL-4 adjustment (P = .01). Active asthma through age 5 years was positively associated with 3-month IL-13 levels adjusted for IFN-γ (odds ratio, 2.6; P < .001) and inversely associated with 3-month IFN-γ levels adjusted for IL-13 (odds ratio, 0.5; P = .001). These relations were strongest for nonatopic asthma.
conclusionTotal IgE levels and active asthma through age 5 years are associated with adaptive cytokine production in early life, although relations vary temporally and with regard to the relative importance of individual cytokines.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.