ArticleBMC microbiology2011
Phylogeography of Francisella tularensis subspecies holarctica from the country of Georgia.
Article in BMC microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Genomic characterization of Francisella tularensis and other diverse Francisella species from complex samples.PloS one · 2022Article
- Reorganized Genomic Taxonomy ofMicroorganisms · 2021Article
- Genetic Traces of theMicroorganisms · 2020Article
- Epidemiologic and Epizootic Data of Tularemia in the Past and in the Recent History in Croatia.Microorganisms · 2020Review
- Genetic Diversity and Spatial Segregation ofFrontiers in cellular and infection microbiology · 2019Article
- Phylogeographic Distribution of Human and HareFrontiers in cellular and infection microbiology · 2019Article
- Variant site strain typer (VaST): efficient strain typing using a minimal number of variant genomic sites.BMC bioinformatics · 2018Article
- RevisitingFrontiers in microbiology · 2018Article
- Phylogenetic Lineages ofFrontiers in cellular and infection microbiology · 2018Review
- Tularemia in Germany-A Re-emerging Zoonosis.Frontiers in cellular and infection microbiology · 2018Review
- Review
- High and novel genetic diversity of Francisella tularensis in Germany and indication of environmental persistence.Epidemiology and infection · 2016Article
- Towards Development of Improved Serodiagnostics for Tularemia by Use of Francisella tularensis Proteome Microarrays.Journal of clinical microbiology · 2016Article
- Environmental Monitoring and Surveillance of Rodents and Vectors for Francisella tularensis Following Outbreaks of Human Tularemia in Georgia.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2015Article
- Diverse Francisella tularensis strains and oropharyngeal tularemia, Turkey.Emerging infectious diseases · 2015Article
- Rapid high resolution genotyping of Francisella tularensis by whole genome sequence comparison of annotated genes ("MLST+").PloS one · 2015Article
- Eight new genomes and synthetic controls increase the accessibility of rapid melt-MAMA SNP typing of Coxiella burnetii.PloS one · 2014Article
- Insights to genetic characterization tools for epidemiological tracking of Francisella tularensis in Sweden.PloS one · 2014Article
- Draft genome sequence of Francisella tularensis subsp. holarctica BD11-00177.Standards in genomic sciences · 2013Article
- German Francisella tularensis isolates from European brown hares (Lepus europaeus) reveal genetic and phenotypic diversity.BMC microbiology · 2013Article
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22 authors.
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Abstract
backgroundFrancisella tularensis, the causative agent of tularemia, displays subspecies-specific differences in virulence, geographic distribution, and genetic diversity. F. tularensis subsp. holarctica is widely distributed throughout the Northern Hemisphere. In Europe, F. tularensis subsp. holarctica isolates have largely been assigned to two phylogenetic groups that have specific geographic distributions. Most isolates from Western Europe are assigned to the B.Br.FTNF002-00 group, whereas most isolates from Eastern Europe are assigned to numerous lineages within the B.Br.013 group. The eastern geographic extent of the B.Br.013 group is currently unknown due to a lack of phylogenetic knowledge about populations at the European/Asian juncture and in Asia. In this study, we address this knowledge gap by describing the phylogenetic structure of F. tularensis subsp. holarctica isolates from the country of Georgia, and by placing these isolates into a global phylogeographic context.
resultsWe identified a new genetic lineage of F. tularensis subsp. holarctica from Georgia that belongs to the B.Br.013 group. This new lineage is genetically and geographically distinct from lineages previously described from the B.Br.013 group from Central-Eastern Europe. Importantly, this new lineage is basal within the B.Br.013 group, indicating the Georgian lineage diverged before the diversification of the other known B.Br.013 lineages. Although two isolates from the Georgian lineage were collected nearby in the Ukrainian region of Crimea, all other global isolates assigned to this lineage were collected in Georgia. This restricted geographic distribution, as well as the high levels of genetic diversity within the lineage, is consistent with a relatively older origin and localized differentiation.
conclusionsWe identified a new lineage of F. tularensis subsp. holarctica from Georgia that appears to have an older origin than any other diversified lineages previously described from the B.Br.013 group. This finding suggests that additional phylogenetic studies of F. tularensis subsp. holarctica populations in Eastern Europe and Asia have the potential to yield important new insights into the evolutionary history and phylogeography of this broadly dispersed F. tularensis subspecies.
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