ArticleMalaria journal2011
Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: a bioassay-guided fractionation of the stem bark.
Article in Malaria journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- GABAergic and α-Glucosidase-Inhibitory Potentials of Fractions and Isolated Xanthones fromMolecules (Basel, Switzerland) · 2025Article
- Bioassay-Guided Isolation of Antiplasmodial Compounds fromBioMed research international · 2023Article
- Hypericum Genus as a Natural Source for Biologically Active Compounds.Plants (Basel, Switzerland) · 2022Review
- Review
- Article
- The Antiplasmodial Potential of Medicinal Plants Used in the Cameroonian Pharmacopoeia: An Updated Systematic Review and Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Antiplasmodial natural products: an update.Malaria journal · 2019Review
- In vitro and in vivo studies on anti-malarial activity of Commiphora africana and Dichrostachys cinerea used by the Maasai in Arusha region, Tanzania.Malaria journal · 2019Article
- Potent antiplasmodial extracts and fractions from Terminalia mantaly and Terminalia superba.Malaria journal · 2018Article
- Review
- The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids.Malaria journal · 2014Review
- The potential of anti-malarial compounds derived from African medicinal plants, part I: a pharmacological evaluation of alkaloids and terpenoids.Malaria journal · 2013Review
- Cameroonian medicinal plants: a bioactivity versus ethnobotanical survey and chemotaxonomic classification.BMC complementary and alternative medicine · 2013Article
- In vivo antioxidant assessment of two antimalarial plants-Allamamda cathartica and Bixa orellana.Asian Pacific journal of tropical biomedicine · 2013Article
- Two series of new semisynthetic triterpene derivatives: differences in anti-malarial activity, cytotoxicity and mechanism of action.Malaria journal · 2013Article
- Article
- Antimicrobial and antioxidant activities of the extracts and compounds from the leaves of Psorospermum aurantiacum Engl. and Hypericum lanceolatum Lam.BMC complementary and alternative medicine · 2012Article
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6 authors.
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Abstract
backgroundMalaria is a major public health threat in Africa, and traditional medicine continues to play a key role in its control especially in rural areas. A bioassay-guided fractionation was carried out in order to evaluate the anti-malarial potential and the safety of the methanol extract of the Hypericum lanceolatum stem bark.
methodsThe anti-plasmodial activity was assayed by the lactate dehydrogenase method (pLDH) against the multidrug-resistant W2mef laboratory strain, and a field isolate (SHF4) of Plasmodium falciparum. Cytotoxicity tests were carried out using the LLC-MK2 monkey kidney epithelial cells.
resultsFive compounds were isolated from the most active and least cytotoxic ethylacetate sub-extract: betulinic acid (HLT1), 2,2',5,6'-tetrahydroxybenzophenone (HLT2), 5-hydroxy-3-methoxyxanthone (HLT3), 3-hydroxy-5-methoxyxanthone (HLT4) and HLT0 (yet to be identified). Three of the tested compounds presented significant anti-plasmodial activities (with 50% inhibitory concentration, IC₅₀ < 5 μM), with 5-hydroxy-3-methoxyxanthone exerting the highest activity, followed by HLT0 and betulinic acid. All the compounds with significant anti-plasmodial activity were non-cytotoxic, except betulinic acid which showed a 50% cytotoxic concentration, CC₅₀ of 25 μg/mL.
conclusionsThese findings justify the use of H. lanceolatum stem bark as anti-malarial by traditional healers of Western Cameroon, and could constitute a good basis for further studies towards development of new drug candidates or phytomedicines for malaria.
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