ArticleHepatology research : the official journal of the Japan Society of Hepatology2011
Activator protein-2α functions as a master regulator of multiple transcription factors in the mouse liver.
Article in Hepatology research : the official journal of the Japan Society of Hepatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- TFAP2A is a component of the ZEB1/2 network that regulates TGFB1-induced epithelial to mesenchymal transition.Biology direct · 2017Article
- Transcriptomic characterization of fibrolamellar hepatocellular carcinoma.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Whole Genome Association Studies of Residual Feed Intake and Related Traits in the Pig.PloS one · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
aimActivator protein 2α (AP-2α) belongs to the AP-2 family of transcription factors that are involved in the regulation of cell proliferation, differentiation, apoptosis and carcinogenesis and has been suggested to function as a tumor suppressor in many cancers. However, the physiological role of AP-2α in hepatocytes is unknown. The present study is to characterize the expression and function of AP-2α in the liver of conscience mouse.
methodsExogenous AP-2α was overexpressed in the mouse liver by in vivo gene delivery and changes in transcription factor expression were identified by using protein-DNA arrays and immunoblotting.
resultsWestern blotting and protein/DNA arrays showed that AP-2α is expressed in the nuclei of mouse hepatocytes. Overexpression of AP-2αin vivo significantly suppressed transcription factors AP-1, CREB and c-Myc, and markedly increased CBF, c-Myb, NF-1, Pax-5, RXR, Smad3/4, TR(DR-4), USF-1 and GATA. Among all GATA proteins, only GATA-4 level was dramatically elevated and there was a concomitant loss of phospho-GATA-4. Corresponding changes were detected in upstream kinases Akt, GSK-3β and PKA, which regulates the phosphorylation status and stability of GATA-4 protein.
conclusionsAP-2α is expressed in mouse hepatocytes and it acts as a master regulator of numerous transcription factors in the liver.
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Registered trials
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