ReviewClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases2011
Strain diversity, epistasis and the evolution of drug resistance in Mycobacterium tuberculosis.
Review in Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
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Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk Factors for Acquired Rifamycin and Isoniazid Resistance: A Systematic Review and Meta-Analysis.PloS one · 2015Pooled it
- Pattern and prevalence of rifampicin and isoniazid-resistant tuberculosis using genotype MTBDRMicrobiology spectrum · 2026Article
- Genomic characterization of XDR Mycobacterium tuberculosis isolates in Argentina (2006-2015).BMC infectious diseases · 2025Article
- Universal Lineage-Independent Markers of Multidrug Resistance inMicroorganisms · 2024Article
- Multidrug-resistant tuberculosis clusters and transmission in Taiwan: a population-based cohort study.Frontiers in microbiology · 2024Article
- GSK2656157, a PERK Inhibitor, Alleviates Pyroptosis of Macrophages Induced by MycobacteriumInternational journal of molecular sciences · 2023Article
- Feature weighted models to address lineage dependency in drug-resistance prediction from Mycobacterium tuberculosis genome sequences.Bioinformatics (Oxford, England) · 2023Article
- The relative transmission fitness of multidrug-resistant Mycobacterium tuberculosis in a drug resistance hotspot.Nature communications · 2023Article
- Article
- Host-pathogen relationship in retreated tuberculosis with major rifampicin resistance-conferring mutations.Frontiers in microbiology · 2023Article
- Review
- Compensatory effects ofEmerging microbes & infections · 2021Article
- Characterization of Mutations Associated with Streptomycin Resistance in Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Evolution of Drug-ResistantFrontiers in microbiology · 2021Review
- Article
- Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease.PLoS genetics · 2020Article
- Targeted surveillance strategies for efficient detection of novel antibiotic resistance variants.eLife · 2020Article
- Whole Genome Sequencing ofFrontiers in microbiology · 2019Article
- Understanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis.Scientific reports · 2018Article
- Epistatic control of intrinsic resistance by virulence genes in Listeria.PLoS genetics · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Mycobacterium tuberculosis harbours little DNA sequence diversity compared with other bacteria. However, there is mounting evidence that strain-to-strain variation in this organism has been underestimated. We review our current understanding of the genetic diversity among M. tuberculosis clinical strains and discuss the relevance of this diversity for the ongoing global epidemics of drug-resistant tuberculosis. Based on findings in other bacteria, we propose that epistatic interactions between pre-existing differences in strain genetic background, acquired drug-resistance-conferring mutations and compensatory changes could play a role in the emergence and spread of drug-resistant M. tuberculosis.
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