Evidence map›Paper›PMID 21682736›Full record

ReviewImmunological reviews2011

The genetics of asthma and allergic disease: a 21st century perspective.

Carole Ober, Tsung-Chieh Yao

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Immunological reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 299 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
299citing papers in PubMed, 14 pooled it
24.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

299 citing papers in PubMed, 14 syntheses or guidelines pooled it, 690 citations in OpenAlex.

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  12. Greenspace and Atopic Sensitization in Children and Adolescents-A Systematic Review.International journal of environmental research and public health · 2018
    Pooled it
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  15. Trial
  16. Differential associations of allergic disease genetic variants with developmental profiles of eczema, wheeze and rhinitis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019
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  18. Metabolomic profiling of lung function in Costa-Rican children with asthma.Biochimica et biophysica acta. Molecular basis of disease · 2017
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  19. Article
  20. Establishment of HAnalytical and bioanalytical chemistry · 2026
    Article

239 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Carole OberDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637, USA. c-ober@genetics.uchicago.edu
Tsung-Chieh Yao
Chang Gung Memorial Hospital · TWUniversity of Chicago · US

Funding

Virus-Bacterial Interactions and Exacerba of AsthmaP01HL070831 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E. · 2002 to 2017
$31.3M
The Asthma BioRepository for Integrative Genomics ResearchRC2HL101543 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI RABY, BENJAMIN ALEXANDER, WEISS, SCOTT T · 2009 to 2010
$8.3M
Sex-Specific Genetic Architecture of Asthma-Associated Quantitative TraitsR01HL085197 · NHLBI · UNIVERSITY OF CHICAGO · PI OBER, CAROLE · 2007 to 2015
$7.6M
The EVE Asthma Genetics Consortium: Building Upon GWASRC2HL101651 · NHLBI · UNIVERSITY OF CHICAGO · PI NICOLAE, DAN LIVIU, OBER, CAROLE · 2009 to 2010
$7.4M
NHLBI NIH HHS HL101543NHLBI NIH HHS HL101651NHLBI NIH HHS HL70831NHLBI NIH HHS HL85197NHLBI NIH HHS P01 HL070831NHLBI NIH HHS R01 HL085197NHLBI NIH HHS RC2 HL101543NHLBI NIH HHS RC2 HL101651
6 · The paper itself

Abstract

Asthma and allergy are common conditions with complex etiologies involving both genetic and environmental contributions. Recent genome-wide association studies (GWAS) and meta-analyses of GWAS have begun to shed light on both common and distinct pathways that contribute to asthma and allergic diseases. Associations with variation in genes encoding the epithelial cell-derived cytokines, interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP), and the IL1RL1 gene encoding the IL-33 receptor, ST2, highlight the central roles for innate immune response pathways that promote the activation and differentiation of T-helper 2 cells in the pathogenesis of both asthma and allergic diseases. In contrast, variation at the 17q21 asthma locus, encoding the ORMDL3 and GSDML genes, is specifically associated with risk for childhood onset asthma. These and other genetic findings are providing a list of well-validated asthma and allergy susceptibility genes that are expanding our understanding of the common and unique biological pathways that are dysregulated in these related conditions. Ongoing studies will continue to broaden our understanding of asthma and allergy and unravel the mechanisms for the development of these complex traits.

Indexed as

AdultAsthmaChildChromosomes, Human, Pair 17CytokinesGasderminsGene Expression RegulationGenetic LinkageGenetic LociGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansHypersensitivity, ImmediateImmunity, InnateInfantCytokinesGasderminsGSDMB protein, humanIL1RL1 protein, humanIL33 protein, humanInterleukin-1 Receptor-Like 1 ProteinInterleukin-33InterleukinsMembrane ProteinsNeoplasm ProteinsORMDL3 protein, humanReceptors, Cell SurfaceThymic Stromal Lymphopoietin

Identifiers

PMID21682736
PMCPMC3151648
OpenAlexW1808276465

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.