ArticleAnnals of human biology2011
Evidence for the intra-uterine programming of adiposity in later life.
Article in Annals of human biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- Weight Gain and Nutrition during Pregnancy: An Analysis of Clinical Practice Guidelines in the Asia-Pacific Region.Nutrients · 2022Pooled it
- The Impact of Maternal Obesity on Offspring Cardiovascular Health: A Systematic Literature Review.Frontiers in endocrinology · 2022Pooled it
- Nongenetic determinants of age at menarche: a systematic review.BioMed research international · 2014Pooled it
- A Daily Snack Containing Leafy Green Vegetables, Fruit, and Milk before and during Pregnancy Prevents Gestational Diabetes in a Randomized, Controlled Trial in Mumbai, India.The Journal of nutrition · 2016Trial
- Reconsidering Obesity in India Through a Gut-Metabolic Lens: Mechanistic Insights and the Emerging Role of Synbiotics in Individuals with the Thin-Fat Phenotype.Advances in therapy · 2026Article
- Review
- Paternal obesity induces subfertility in male offspring by modulating the oxidative stress-related transcriptional network.International journal of obesity (2005) · 2024Article
- Article
- Origin of the neonatal gut microbiota and probiotic intervention: a randomized controlled trial.Frontiers in nutrition · 2024Article
- FTO and MC4R polymorphisms, and selected pre-, peri- and postnatal factors as determinants of body mass index and fatness in children: a thorough analysis of the associations.Journal of physiological anthropology · 2023Article
- Physical, Metabolic, and Microbial Rumen Development in Goat Kids: A Review on the Challenges and Strategies of Early Weaning.Animals : an open access journal from MDPI · 2023Review
- Association between Birth Weight and Subcutaneous Fat Thickness at Adulthood in Dogs.Veterinary sciences · 2023Article
- Multigenerational diabetes mellitus.Frontiers in endocrinology · 2023Review
- Paternal high-fat diet alters triglyceride metabolism-related gene expression in liver and white adipose tissue of male mouse offspring.Biochemistry and biophysics reports · 2022Article
- Metabolic-endocrine disruption due to preterm birth impacts growth, body composition, and neonatal outcome.Pediatric research · 2022Review
- Gestational weight change and childhood body composition trajectories from pregnancy to early adolescence.Obesity (Silver Spring, Md.) · 2022Article
- Omega-6 Fatty Acids: A Sustainable Alternative to Improve Beef Production Efficiency.Animals : an open access journal from MDPI · 2021Review
- Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study: newborn anthropometrics and childhood glucose metabolism.Diabetologia · 2021Article
- Impact of Early Nutrition, Physical Activity and Sleep on the Fetal Programming of Disease in the Pregnancy: A Narrative Review.Nutrients · 2020Review
- Fetal exposure to phthalates and bisphenols and childhood general and organ fat. A population-based prospective cohort study.International journal of obesity (2005) · 2020Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
aimResearch in animals has shown that altering foetal nutrition by under-nourishing or over-nourishing the mother or rendering her diabetic or foetal exposure to glucocorticoids and toxins can programme obesity in later life. The increased adiposity is mediated by permanent changes in appetite, food choices, physical activity and energy metabolism. In humans, increased adiposity has been shown in people who experienced foetal under-nutrition due to maternal famine or over-nutrition due to maternal diabetes. Lower birth weight (a proxy for foetal under-nutrition) is associated with a reduced adult lean mass and increased intra-abdominal fat. Higher birth-weight caused by maternal diabetes is associated with increased total fat mass and obesity in later life. There is growing evidence that maternal obesity, without diabetes, is also a risk factor for obesity in the child, due to foetal over-nutrition effects. Maternal smoking is associated with an increased risk of obesity in the children, although a causal link has not been proven. Other foetal exposures associated with increased adiposity in animals include glucocorticoids and endocrine disruptors.
conclusionsReversing the current obesity epidemic will require greater attention to, and better understanding of, these inter-generational (mother-offspring) factors that programme body composition during early development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.