ArticleJournal of materials science. Materials in medicine2011
Analysis of the cytotoxicity of differentially sized titanium dioxide nanoparticles in murine MC3T3-E1 preosteoblasts.
Article in Journal of materials science. Materials in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Titanium dioxide dental implants surfaces related oxidative stress in bone remodeling: a systematic review.PeerJ · 2022Pooled it
- Cytotoxic effects of submicron- and nano-scale titanium debris released from dental implants: an integrative review.Clinical oral investigations · 2021Pooled it
- Article
- Investigation of Topographical Alterations in Titanium-Zirconium-Alloy Implant Threads following Er:YAG Irradiation.Materials (Basel, Switzerland) · 2022Article
- Article
- Use of nanoparticles in skeletal tissue regeneration and engineering.Histology and histopathology · 2020Review
- Local Cellular Responses to Metallic and Ceramic Nanoparticles from Orthopedic Joint Arthroplasty Implants.International journal of nanomedicine · 2020Review
- Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation.International journal of molecular medicine · 2019Article
- Penetration, distribution and brain toxicity of titanium nanoparticles in rodents' body: a review.IET nanobiotechnology · 2018Review
- Local Cellular Responses to Titanium Dioxide from Orthopedic Implants.BioResearch open access · 2017Review
- Enhanced osteogenic activity and anti-inflammatory properties of Lenti-BMP-2-loaded TiO₂ nanotube layers fabricated by lyophilization following trehalose addition.International journal of nanomedicine · 2016Article
- Cytotoxicity of Titanate-Calcium Complexes to MC3T3 Osteoblast-Like Cells.BioMed research international · 2016Article
- Titanium dioxide nanoparticles enhance production of superoxide anion and alter the antioxidant system in human osteoblast cells.International journal of nanomedicine · 2015Article
- Article
- Combination of small size and carboxyl functionalisation causes cytotoxicity of short carbon nanotubes.Nanotoxicology · 2013Article
- Health effects of exposure to nano-TiO2: a meta-analysis of experimental studies.Nanoscale research letters · 2013Article
- In vitro cytotoxicity of surface modified bismuth nanoparticles.Journal of materials science. Materials in medicine · 2012Article
- Nanoparticles and their potential for application in bone.International journal of nanomedicine · 2012Review
- The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles.International journal of nanomedicine · 2012Review
- Apoptosis of Adipose-Derived Stem Cells Induced by Liposomal Soybean Phosphatidylcholine Extract.Avicenna journal of medical biotechnologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is an increased use of nanophase titanium dioxide (TiO(2)) in bone implants and scaffolds. However, nano-debris is generated at the bone-biomaterial interface. Therefore, TiO(2) nanoparticles (NPs) of many sizes were investigated for cytotoxic effects on murine MC3T3-E1 preosteoblasts. These TiO(2) NPs induced a time- and dose-dependent decrease in cell viability. There was a significant increase in lactate dehydrogenase (LDH) release, apoptosis and mitochondrial membrane permeability following short-term exposure of the cells to TiO(2) NPs. These NPs also increased granulocyte-macrophage colony stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) gene expression. Compared with the 32 nm TiO(2) NPs, 5 nm TiO(2) NPs were more toxic, induced more apoptosis, increased mitochondrial membrane permeability and stimulated more GM-CSF expression at a high concentration (≥100 μg/ml). The results implied that the differential toxicity was associated with variations in size, so more attention should be given to the toxicity of small NPs for the design of future materials for implantation.
Indexed as
Identifiers
21681655What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.