ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2012
Repair of osteochondral lesions in the knee by chondrocyte implantation using the MACI® technique.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Osteochondral tissue engineering approaches for articular cartilage and subchondral bone regeneration.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2012Pooled it
- Matrix-induced autologous chondrocyte implantation (MACI) for chondral defects in the patellofemoral joint.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2014Trial
- The osteochondral regeneration paradox: why biomimetic scaffolds are biologically superior but injectable systems dominate the clinic.RSC advances · 2026Review
- Bone marrow edema-like signal after cartilage repair does not affect outcomes in a five-year follow-up.European radiology · 2025Article
- Long-term Assessment of Subchondral Bone Changes and Intralesional Bony Overgrowth After Third-Generation Autologous Chondrocyte Implantation: A Retrospective Study.The American journal of sports medicine · 2023Article
- Accurate Reporting of Concomitant Procedures Is Highly Variable in Studies Investigating Knee Cartilage Restoration.Cartilage · 2021Article
- The Good the Bad and the Ugly of Glycosaminoglycans in Tissue Engineering Applications.Pharmaceuticals (Basel, Switzerland) · 2017Review
- Mesenchymal Stem and Progenitor Cells in Regeneration: Tissue Specificity and Regenerative Potential.Stem cells international · 2017Review
- Experimental articular cartilage repair in the Göttingen minipig: the influence of multiple defects per knee.Journal of experimental orthopaedics · 2015Article
- The current state of scaffolds for musculoskeletal regenerative applications.Nature reviews. Rheumatology · 2015Review
- Is the clinical outcome after cartilage treatment affected by subchondral bone edema?Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2014Article
- Use of innovative biomimetic scaffold in the treatment for large osteochondral lesions of the knee.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2014Article
- Early resumption of physical activities leads to inferior clinical outcomes after matrix-based autologous chondrocyte implantation in the knee.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2014Article
- Graft hypertrophy of matrix-based autologous chondrocyte implantation: a two-year follow-up study of NOVOCART 3D implantation in the knee.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2014Article
- Matrix-induced autologous chondrocyte implantation for the treatment of chondral defects of the knees in Chinese patients.Drug design, development and therapy · 2014Article
- The use of fibrin matrix-mixed gel-type autologous chondrocyte implantation in the treatment for osteochondral lesions of the talus.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2013Article
- Matrix assisted autologous chondrocyte transplantation for cartilage treatment: A systematic review.Bone & joint research · 2013Article
- Advances in the Surgical Management of Articular Cartilage Defects: Autologous Chondrocyte Implantation Techniques in the Pipeline.Cartilage · 2013Article
- Trends in biological joint resurfacing.Bone & joint research · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMatrix-associated autologous chondrocyte implantation (MACI(®)) is an innovative therapeutic option for the treatment of chondral and osteochondral lesions of the knee.
methodsFifty-three patients (54 knees) with MRI-documented osteochondral lesions were treated with MACI(®). A clinical assessment was performed using VAS score, Lysholm score, and Tegner activity level after an average follow-up of 27 months (SD: 2.3). MRI scans were performed 12 and 24 months after surgery. Seventeen patients were reevaluated after an average time of 59 months (SD: 6.7) after surgery.
resultsTwo years after transplantation, Lysholm score increased from a preoperative mean value of 70 (SD: 13.4) to 95 (SD: 6.4); the average VAS score decreased from a preoperative value of 5.2 (SD: 2.9) to 1.9 (SD: 2.1). The difference with respect to Tegner activity level did not prove to be significant. At 1 year, MRI scans documented a completely repaired defect with slight subchondral bone abnormality in 38 cases (70%). Satisfying outcomes were confirmed on 17 patients who were reevaluated 5 years after surgery. At 60 months, MRI scans showed complete integration with the surrounding native cartilage without any sign of detachment or bone marrow edema in 15 cases (88%).
conclusionThe MACI(®) technique is a safe and clinically effective procedure, which has been proven to be valuable in treating osteochondral defects even over the long term. LEVEL OF EVIDENCE: Therapeutic study, Level III-2 (retrospective cohort study).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.