ArticleEuropean journal of nutrition2012
S-allylmercaptocysteine reduces carbon tetrachloride-induced hepatic oxidative stress and necroinflammation via nuclear factor kappa B-dependent pathways in mice.
Article in European journal of nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
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- Melatonin alleviates alcoholic liver diseaseActa pharmaceutica Sinica. B · 2023Article
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- S-allylmercaptocysteine improves nonalcoholic steatohepatitis by enhancing AHR/NRF2-mediated drug metabolising enzymes and reducing NF-κB/IκBα and NLRP3/6-mediated inflammation.European journal of nutrition · 2021Article
- Role of Nutraceuticals in COVID-19 Mediated Liver Dysfunction.Molecules (Basel, Switzerland) · 2020Review
- Beneficial effect of aged garlic extract on periodontitis: a randomized controlled double-blind clinical study.Journal of clinical biochemistry and nutrition · 2020Article
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- Garlic-derived compoundActa pharmaceutica Sinica. B · 2018Article
- Effects of exogenous thymosin β4 on carbon tetrachloride-induced liver injury and fibrosis.Scientific reports · 2017Article
- Protective Effects of Garlic-Derived S-Allylmercaptocysteine on IL-1BioMed research international · 2017Article
- Protective Effect of Procyanidin B2 against CCl4-Induced Acute Liver Injury in Mice.Molecules (Basel, Switzerland) · 2015Article
- Investigation of estrogen receptor (ESR1) for breast cancer from traditional Chinese medicine.BioMed research international · 2014Article
- An investigation of small GTPases in relation to liver tumorigenesis using traditional Chinese medicine.BioMed research international · 2014Article
- Recent advances in the herbal treatment of non-alcoholic Fatty liver disease.Journal of traditional and complementary medicine · 2013Review
- Garlic-derived S-allylmercaptocysteine is a hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model.European journal of nutrition · 2013Article
- Garlic-Derived S-Allylmercaptocysteine Ameliorates Nonalcoholic Fatty Liver Disease in a Rat Model through Inhibition of Apoptosis and Enhancing Autophagy.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Ameliorating effect of Allium Sativum on high-fat diet induced fatty liver in albino rats.Pakistan journal of medical sciencesArticle
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo study the protective effects and underlying molecular mechanisms of SAMC on carbon tetrachloride (CCl4)-induced acute hepatotoxicity in the mouse model.
methodsMice were intraperitoneally injected with CCl4 (50 μl/kg; single dose) to induce acute hepatotoxicity with or without a 2-h pre-treatment of SAMC intraperitoneal injection (200 mg/kg; single dose). After 8 h, the blood serum and liver samples of mice were collected and subjected to measurements of histological and molecular parameters of hepatotoxicity.
resultsSAMC reduced CCl4-triggered cellular necrosis and inflammation in the liver under histological analysis. Since co-treatment of SAMC and CCl4 enhanced the expressions of antioxidant enzymes, reduced the nitric oxide (NO)-dependent oxidative stress, and inhibited lipid peroxidation induced by CCl4. SAMC played an essential antioxidative role during CCl4-induced hepatotoxicity. Administration of SAMC also ameliorated hepatic inflammation induced by CCl4 via inhibiting the activity of NF-κB subunits p50 and p65, thus reducing the expressions of pro-inflammatory cytokines, mediators, and chemokines, as well as promoting pro-regenerative factors at both transcriptional and translational levels.
conclusionsOur results indicate that SAMC mitigates cellular damage, oxidative stress, and inflammation in CCl4-induced acute hepatotoxicity mouse model through regulation of NF-κB. Garlic or garlic derivatives may therefore be a potential food supplement in the prevention of liver damage.
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