Evidence map›Paper›PMID 21681211›Full record

ReviewNature reviews. Genetics2011

Genome-wide genetic marker discovery and genotyping using next-generation sequencing.

John W Davey, Paul A Hohenlohe, Paul D Etter, Jason Q Boone, Julian M Catchen, Mark L Blaxter

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,004 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,004citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,004 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Genetic dissection of grain yield and correlated proxy traits under suboptimal conditions.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
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944 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

John W DaveyInstitute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, King's Buildings, West Mains Road, Edinburgh, EH9 3JT, UK. john.davey@ed.ac.uk
Paul A Hohenlohe
Paul D Etter
Jason Q Boone
Julian M Catchen
Mark L Blaxter

Funding

Rapid and flexible SNP discovery and genotypingR21HG003834 · NHGRI · UNIVERSITY OF OREGON · PI JOHNSON, ERIC A · 2008 to 2009
$402k
Conversion of short-read sequence data to locally-assembled long contigsR21HG006036 · NHGRI · UNIVERSITY OF OREGON · PI JOHNSON, ERIC A · 2011 to 2012
$391k
SUBUNIT INTERACTIONS DURING ASSEMBLY OF H+-ATPASEF32GM009521 · NIGMS · STANFORD UNIVERSITY · PI CAIN, BRIAN D. · 1985 to 1985
–
Biotechnology and Biological Sciences Research Council BB/F021135/1Biotechnology and Biological Sciences Research Council BB/G00661X/1Biotechnology and Biological Sciences Research Council BB/H023844/1Medical Research Council G0900740NHGRI NIH HHS R21HG003834NHGRI NIH HHS R21HG006036NIGMS NIH HHS 1F32GM095213‑01NIGMS NIH HHS 1R24GM079486‑01A1
6 · The paper itself

Abstract

The advent of next-generation sequencing (NGS) has revolutionized genomic and transcriptomic approaches to biology. These new sequencing tools are also valuable for the discovery, validation and assessment of genetic markers in populations. Here we review and discuss best practices for several NGS methods for genome-wide genetic marker development and genotyping that use restriction enzyme digestion of target genomes to reduce the complexity of the target. These new methods -- which include reduced-representation sequencing using reduced-representation libraries (RRLs) or complexity reduction of polymorphic sequences (CRoPS), restriction-site-associated DNA sequencing (RAD-seq) and low coverage genotyping -- are applicable to both model organisms with high-quality reference genome sequences and, excitingly, to non-model species with no existing genomic data.

Indexed as

Genetic MarkersAlgorithmsAnimalsChromosome MappingGenetic Association StudiesGenomeGenomicsGenotypeHigh-Throughput Nucleotide SequencingHumansModels, BiologicalGenetic Markers

Identifiers

PMID21681211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.