ArticleAJNR. American journal of neuroradiology2011
Fully automated atlas-based MR imaging volumetry in Huntington disease, compared with manual volumetry.
Article in AJNR. American journal of neuroradiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Multiparametric MRI-based biomarkers in the non-fluent and semantic variants of primary progressive aphasia.Journal of neurology · 2025Article
- Reduced-penetrance Huntington's disease-causing alleles with 39 CAG trinucleotide repeats could be a genetic factor of amyotrophic lateral sclerosis.Journal of the Chinese Medical Association : JCMA · 2023Article
- Validating Automated Segmentation Tools in the Assessment of Caudate Atrophy in Huntington's Disease.Frontiers in neurology · 2021Article
- SeSBAT: Single Subject Brain Analysis Toolbox. Application to Huntington's Disease as a Preliminary Study.Frontiers in systems neuroscience · 2020Article
- The applause sign in frontotemporal lobar degeneration and related conditions.Journal of neurology · 2019Article
- Atrophy in the Thalamus But Not Cerebellum Is Specific forFrontiers in aging neuroscience · 2018Article
- Volumetric assessment of optic nerve sheath and hypophysis in idiopathic intracranial hypertension.AJNR. American journal of neuroradiology · 2014Article
- Chromatin plasticity and the pathogenesis of Huntington disease.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe atrophy of the caudate is considered the hallmark of HD-associated neurodegeneration and has high potential as a biomarker in structural MR imaging. This study aimed at comparing automated and manual caudate volumetry. MATERIALS AND
methodsIn this cross-sectional volumetric study in 40 patients with HD and 30 healthy controls, a fully automated caudate measurement by ABV was used for the first time in HD and was directly compared with manual delineation as the generally accepted criterion standard of volumetry.
resultsIt could be shown that both techniques were able to separate patients and controls to a similar degree. The differences between the 2 volumetric measurements ranged within the limits of agreement; the systematically lower values by manual volumetry were caused by the different assessment of the dorsal caudate tail, which is hard to delineate manually.
conclusionsABV may be used instead of manual volumetry to quantify caudate volume loss. Additionally, the ABV technique has the advantage of being much faster, is less laborious, and is free of a subjective region-of interest definition. ABV might serve as a tool in potential future clinical trials of disease-modifying treatments in HD.
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