ArticleThe journal of pain2011
Elevated pain sensitivity in chronic pain patients at risk for opioid misuse.
Article in The journal of pain, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 109 citations in OpenAlex.
- Augmenting the efficacy of benzodiazepine taper with telehealth-delivered cognitive behavioral therapy for anxiety disorders in patients using prescription opioids: A pilot randomized controlled trial.Contemporary clinical trials · 2023Trial
- The Effects of Combined Respiratory-Gated Auricular Vagal Afferent Nerve Stimulation and Mindfulness Meditation for Chronic Low Back Pain: A Pilot Study.Pain medicine (Malden, Mass.) · 2022Trial
- Trial
- Changes in Pain Sensitivity and Pain Modulation During Oral Opioid Treatment: The Impact of Negative Affect.Pain medicine (Malden, Mass.) · 2016Trial
- The Contribution of Differential Opioid Responsiveness to Identification of Opioid Risk in Chronic Pain Patients.The journal of pain · 2015Trial
- Trial
- Trial
- Evoked pain analgesia in chronic pelvic pain patients using respiratory-gated auricular vagal afferent nerve stimulation.Pain medicine (Malden, Mass.) · 2012Trial
- Somatosensory Function and Pain: Associations Over 12 Months Postinjury in Youth With Acute Musculoskeletal Pain.The Clinical journal of pain · 2026Article
- Association between preoperative obstructive sleep apnea diagnosis and prolonged postoperative opioid use among patients undergoing common surgical procedures.Regional anesthesia and pain medicine · 2025Article
- Article
- Trends in Celecoxib Prescribing: A Single Institution 16-Month Review.Journal of clinical medicine · 2025Article
- Mediating Effect of Pain Sensitization on the Paradoxical Relation of Taking Opioids to Pain Severity in Knee Osteoarthritis: The Multicenter Osteoarthritis Study.Arthritis care & research · 2024Article
- The effects of sleep restriction during abstinence on oxycodone seeking: Sex-dependent moderating effects of behavioral and hypothalamic-pituitary-adrenal axis-related phenotypes.Physiology & behavior · 2023Article
- Risk Factors for Self-Harm Ideation Among Persons Treated With Opioids for Chronic Low Back Pain.The Clinical journal of pain · 2023Article
- Article
- Temporal associations between use of psychoactive substances and somatic symptoms in the daily lives of people with fibromyalgia.Pain medicine (Malden, Mass.) · 2023Article
- Digital Biomarker Applications Across the Spectrum of Opioid Use Disorder.Cogent mental health · 2023Article
- Emotional distress and pain catastrophizing predict cue-elicited opioid craving among chronic pain patients on long-term opioid therapy.Drug and alcohol dependence · 2022Article
- Profiling and Association over Time between Disability and Pain Features in Patients with Chronic Nonspecific Neck Pain: A Longitudinal Study.Journal of clinical medicine · 2022Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
unlabelledThis study employed quantitative sensory testing (QST) to evaluate pain responses in chronic spinal pain patients at low risk and high risk for opioid misuse, with risk classification based on scores on the Screener and Opioid Assessment for Patients with Pain-Revised (SOAPP-R). Patients were further subgrouped according to current use of prescription opioids. Of the 276 chronic pain patients tested, approximately 65% were taking opioids; a median split was used to further categorize these patients as being on lower or higher doses of opioids. The high-risk group (n = 161) reported higher levels of clinical pain, had lower pressure and thermal pain thresholds at multiple body sites, had lower heat pain tolerance, and rated repetitive mechanical stimuli as more painful relative to the low-risk group (n = 115; P's < .01). In contrast, QST measures did not differ across opioid groups. Multiple linear regression analysis suggested that indices of pain-related distress (ie, anxiety and catastrophizing about pain) were also predictive of hyperalgesia, particularly in patients taking opioids. Collectively, regardless of opioid status, the high-risk group was hyperalgesic relative to the low-risk group; future opioid treatment studies may benefit from the classification of opioid risk, and the examination of pain sensitivity and other factors that differentiate high- and low-risk groups. PERSPECTIVE: This study demonstrates that chronic spinal pain patients at high risk for misuse of prescription opioids are more pain-sensitive than low-risk patients, whether or not they are currently taking opioids. Indices of pain-related distress were important predictors of pain sensitivity, particularly among those patients taking opioids for pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.