Evidence map›Paper›PMID 21680251›Full record

Trial reportThe journal of pain2011

Reciprocal relationship between pain and depression: a 12-month longitudinal analysis in primary care.

Kurt Kroenke, Jingwei Wu, Matthew J Bair, Erin E Krebs, Teresa M Damush, Wanzhu Tu

3 registry-linked trialsAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of pain, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 273 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
273citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04089670 nacompletednot on this mapstarted 2019, after this paper: background citation

Online Acceptance and Commitment Therapy for Chronic Pain in Sample of People With Chiari Malformation

TypeinterventionalSponsorKent State UniversityRan2019 to 2020Enrolled52ConditionsChronic Pain, Chiari MalformationArmsOnline Acceptance and Commitment Therapy Intervention
NCT04248725 nacompletednot on this mapstarted 2020, after this paper: background citation

Efficacy of a Telehealth Pain Self-Management Intervention in Employed Adults With Physical Disability: A Randomized Controlled Trial

TypeinterventionalSponsorUniversity of WashingtonRan2020 to 2024Enrolled220ConditionsChronic Pain, Brain Injuries, Traumatic, Multiple Sclerosis, Spinal Cord InjuriesArmsE-TIPS
NCT06355414 phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Psilocybin and Affective Function in Chronic Lower Back Pain Depression

TypeinterventionalSponsorJohns Hopkins UniversityRan2024 to 2026Enrolled40ConditionsChronic Low-back Pain, DepressionArmsPsilocybin, Methylphenidate
3 · Its place in the literature

Who cites it

273 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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213 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kurt KroenkeDepartment of Medicine, Indiana University, Indianapolis, IN, USA. kkroenke@regenstrief.org
Jingwei Wu
Matthew J Bair
Erin E Krebs
Teresa M Damush
Wanzhu Tu

Funding

Stepped Care for Depression and Musculoskeletal PainR01MH071268 · NIMH · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI KROENKE, KURT · 2004 to 2007
$2.7M
NIMH NIH HHS MH-071268NIMH NIH HHS R01 MH071268
6 · The paper itself

Abstract

unlabelledPain and depression are the most prevalent physical and psychological symptom-based disorders, respectively, and co-occur 30 to 50% of the time. However, their reciprocal relationship and potentially causative effects on one another have been inadequately studied. Longitudinal data analysis involving 500 primary care patients with persistent back, hip, or knee pain were enrolled in the Stepped Care for Affective Disorders and Musculoskeletal Pain (SCAMP) study. Half of the participants had comorbid depression and were randomized to a stepped care intervention (n = 123) or treatment as usual (n = 127). Another 250 nondepressed patients with similar pain were followed in a parallel cohort. Outcomes were assessed at baseline, 3, 6, and 12 months. Mixed effects model repeated measures (MMRM) multivariable analyses were conducted to determine if change in pain severity predicted subsequent depression severity, and vice versa. Change in pain was a strong predictor of subsequent depression severity (t-value = 6.63, P < .0001). Likewise, change in depression severity was an equally strong predictor of subsequent pain severity (t-value = 7.28, P < .0001). Results from the full cohort were similar in the clinical trial subgroup. In summary, pain and depression have strong and similar effects on one another when assessed longitudinally over 12 months. PERSPECTIVE: This study strengthens the evidence for a bidirectional and potentially causative influence of pain and depression on one another. A change in severity of either symptom predicts subsequent severity of the other symptom. Thus, recognition and management of both conditions may be warranted, particularly when treatment focused on 1 condition is not leading to an optimal response.

Indexed as

Primary Health CareAdultAgedCohort StudiesCross-Sectional StudiesDepressionFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedPain

Identifiers

PMID21680251
PMCPMC3222454

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.