Evidence map›Paper›PMID 21679950›Full record

ArticleAtherosclerosis2011

Carotid artery intima-media thickness in college students: race/ethnicity matters.

Carrie V Breton, Xinhui Wang, Wendy J Mack, Kiros Berhane, Milena Lopez, Talat S Islam, Mei Feng, Howard N Hodis, Nino Künzli, Ed Avol

Open access · greenAbstract read
In one paragraph

Article in Atherosclerosis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 37 citations in OpenAlex.

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  5. Race, cortisol, and subclinical cardiovascular disease in 9- to 11-year-old children.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Carrie V BretonUniversity of Southern California, Dept of Preventive Medicine, Los Angeles, CA, United States. breton@usc.edu
Xinhui Wang
Wendy J Mack
Kiros Berhane
Milena Lopez
Talat S Islam
Mei Feng
Howard N Hodis
Nino Künzli
Ed Avol
University of Southern California · USUniversity of Basel · CH

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Urban Air Pollution &Persistent Early Life AsthmaP01ES009581 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GILLILAND, FRANK D. · 1999 to 2010
$6.8M
Air Pollution, Intima-media Thickness, and Lung Function in College StudentsR01ES014708 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AVOL, EDWARD · 2006 to 2010
$4.0M
Prenatal air pollution, DNA methylation and early signs of atherosclerosisK01ES017801 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRETON, CARRIE VAN DOREN · 2010 to 2014
$652k
NIEHS NIH HHS 5P30ES007048NIEHS NIH HHS 5R01ES014708NIEHS NIH HHS K01 ES017801NIEHS NIH HHS P01 ES009581NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R01 ES014708
6 · The paper itself

Abstract

objectiveRacial/ethnic differences in common carotid artery intima-media thickness (CIMT) and in risk factors associated with CIMT have been predominantly observed in middle-aged and older individuals. We aimed to characterize racial/ethnic differences CIMT and other cardiovascular risk factors in a healthy, young-adult population.

methodsCollege students were recruited as part of a study to characterize determinants of atherogenesis. Students were eligible if they were lifetime non-smokers, lived in the United States since six months of age, and attended high school in the United States. Blood pressure, heart rate, height, and weight were measured, B-mode carotid ultrasound was performed, questionnaires were administered and a 12-h fasting blood sample was collected. Associations between CIMT and other variables were assessed in 768 students aged 18-25 years using linear regression analysis.

resultsIn models adjusted for common cardiovascular risk factors, sex exhibited the strongest influence on CIMT, with men having 15.4 μm larger CIMT compared to women (95%CI 6.6, 24.2). Race/ethnicity was also strongly associated with CIMT. African Americans had 17.3 μm greater CIMT (95%CI -0.3, 34.8) compared to non Hispanic Whites, whereas Asians and Hispanic Whites had 14.3 (95%CI -24.3, -4.4) and 15.4 (95%CI -26.2, -4.7) μm smaller CIMT, respectively. BMI and systolic blood pressure were positively associated with CIMT.

conclusionThe risk factors associated with atherogenesis later in life are already present and observable in college-aged young adults, so targeted campaigns to reduce life-long cardiovascular disease burden should be initiated earlier in life to improve public health.

Indexed as

AdolescentAdultAsian PeopleBlack or African AmericanBlood PressureBody Mass IndexCaliforniaCarotid ArteriesCarotid Artery DiseasesChi-Square DistributionCross-Sectional StudiesEthnicityFemaleHispanic or LatinoHumansLinear Models

Identifiers

PMID21679950
PMCPMC3146627
OpenAlexW2086198531

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.