ArticleBiological psychiatry2011
FosB is essential for the enhancement of stress tolerance and antagonizes locomotor sensitization by ΔFosB.
Article in Biological psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Voluntary Physical Activity Modulates Brain ΔFOSB and Alters Coactivation Networks in Male and Female Mice.eNeuro · 2026Article
- The double-edged sword effect of adverse childhood experiences forging adult stress into depression and anxiety.Scientific reports · 2025Article
- Interleukin-17A Mediates Hippocampal Damage and Aberrant Neurogenesis Contributing to Epilepsy-Associated Anxiety.Frontiers in molecular neuroscience · 2022Article
- Functional Divergence of Mammalian TFAP2a and TFAP2b Transcription Factors for Bidirectional Sleep Control.Genetics · 2020Article
- Sleep Deprivation Alters the Pituitary Stress Transcriptome in Male and Female Mice.Frontiers in endocrinology · 2019Article
- Neuronal hypothalamic regulation of body metabolism and bone density is galanin dependent.The Journal of clinical investigation · 2018Article
- Serum Response Factor (SRF) Ablation Interferes with Acute Stress-Associated Immediate and Long-Term Coping Mechanisms.Molecular neurobiology · 2017Article
- Stress-Induced Locomotor Sensitization to Amphetamine in Adult, but not in Adolescent Rats, Is Associated with Increased Expression of ΔFosB in the Nucleus Accumbens.Frontiers in behavioral neuroscience · 2016Article
- Differential induction of FosB isoforms throughout the brain by fluoxetine and chronic stress.Neuropharmacology · 2015Article
- ∆FosB: a transcriptional regulator of stress and antidepressant responses.European journal of pharmacology · 2015Review
- Functional role of the N-terminal domain of ΔFosB in response to stress and drugs of abuse.Neuroscience · 2015Article
- Article
- Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens.Genome biology · 2014Article
- Fluoxetine epigenetically alters the CaMKIIα promoter in nucleus accumbens to regulate ΔFosB binding and antidepressant effects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Ethanol conditioned place preference and alterations in ΔFosB following adolescent nicotine administration differ in rats exhibiting high or low behavioral reactivity to a novel environment.Behavioural brain research · 2014Article
- Second messenger/signal transduction pathways in major mood disorders: moving from membrane to mechanism of action, part I: major depressive disorder.CNS spectrums · 2013Review
- fosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Long-term exercise is a potent trigger for ΔFosB induction in the hippocampus along the dorso-ventral axis.PloS one · 2013Article
- Differential modulation of cocaine's discriminative cue by repeated and variable stress exposure: relation to monoamine transporter levels.Neuropharmacology · 2012Article
- Review of pharmacological treatment in mood disorders and future directions for drug development.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundMolecular mechanisms underlying stress tolerance and vulnerability are incompletely understood. The fosB gene is an attractive candidate for regulating stress responses, because ΔFosB, an alternative splice product of the fosB gene, accumulates after repeated stress or antidepressant treatments. On the other hand, FosB, the other alternative splice product of the fosB gene, expresses more transiently than ΔFosB but exerts higher transcriptional activity. However, the functional differences of these two fosB products remain unclear.
methodsWe established various mouse lines carrying three different types of fosB allele, wild-type (fosB(+)), fosB-null (fosB(G)), and fosB(d) allele, which encodes ΔFosB but not FosB, and analyzed them in stress-related behavioral tests.
resultsBecause fosB(+/d) mice show enhanced ΔFosB levels in the presence of FosB and fosB(d/d) mice show more enhanced ΔFosB levels in the absence of FosB, the function of FosB can be inferred from differences observed between these lines. The fosB(+/d) and fosB(d/d) mice showed increased locomotor activity and elevated Akt phosphorylation, whereas only fosB(+/d) mice showed antidepressive-like behaviors and increased E-cadherin expression in striatum compared with wild-type mice. In contrast, fosB-null mice showed increased depression-like behavior and lower E-cadherin expression.
conclusionsThese findings indicate that FosB is essential for stress tolerance mediated by ΔFosB. These data suggest that fosB gene products have a potential to regulate mood disorder-related behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.