SynthesisNutrition (Burbank, Los Angeles County, Calif.)
Micronutrient supplementation for critically ill adults: a systematic review and meta-analysis.
Synthesis in Nutrition (Burbank, Los Angeles County, Calif.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04029675 (The Effect of High Dose of Vitamin C on the Clinical Outcome of Mechanically Ventilated Patients Following Sepsis in Intensive Care Unit), which is not on this map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of High Dose of Vitamin C on the Clinical Outcome of Mechanically Ventilated Patients Following Sepsis in Intensive Care Unit
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- The effect of selenium therapy in critically ill patients: an umbrella review of systematic reviews and meta-analysis of randomized controlled trials.European journal of medical research · 2023Pooled it
- Small studies may overestimate the effect sizes in critical care meta-analyses: a meta-epidemiological study.Critical care (London, England) · 2013Pooled it
- Antioxidant micronutrients in the critically ill: a systematic review and meta-analysis.Critical care (London, England) · 2012Pooled it
- Article
- Biochemical Changes in Cardiopulmonary Bypass in Cardiac Surgery: New Insights.Journal of personalized medicine · 2023Review
- [Immunomodulation by nutritional intervention in critically ill patients].Die Anaesthesiologie · 2023Review
- Micronutrient Deficiencies in Medical and Surgical Inpatients.Journal of clinical medicine · 2019Review
- Oxidative Stress and Neonatal Respiratory Extracorporeal Membrane Oxygenation.Frontiers in physiology · 2018Review
- The Effect of High-dose Parenteral Sodium Selenite in Critically Ill Patients following Sepsis: A Clinical and Mechanistic Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2017Article
- The effect of parenteral selenium on outcomes of mechanically ventilated patients following sepsis: a prospective randomized clinical trial.Annals of intensive care · 2015Article
- Influence of antioxidant therapy on the clinical status of multiple trauma patients. A retrospective single center study.Romanian journal of anaesthesia and intensive care · 2015Article
- The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill.Physiological reviews · 2015Review
- Metabolic and nutritional support of critically ill patients: consensus and controversies.Critical care (London, England) · 2015Review
- Health economics evidence for medical nutrition: are these interventions value for money in integrated care?ClinicoEconomics and outcomes research : CEOR · 2014Review
- Does artificial nutrition improve outcome of critical illness?Critical care (London, England) · 2013Review
- Micronutrients against oxidative stress--time for clinical recommendations?Critical care (London, England) · 2012Article
- Antioxidants and micronutrient supplementation in trauma patients.Current opinion in clinical nutrition and metabolic care · 2012Review
- Efficacy of commercial formulas in comparison with home-made formulas for enteral feeding: A critical review.Medical journal of the Islamic Republic of IranReview
Corrections and comments
- Commented on byMicronutrients.2011
- Commented on by
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis systematic review assessed the effects of micronutrient supplementation on adults recovering from critical illness. Primary outcomes included clinical endpoints (mortality, infectious complications, length of intensive care unit and of hospital stay). Secondary outcomes included descriptions of practice issues, micronutrient status, morbidity, course of the acute-phase response, and oxidative stress.
methodsElectronic bibliographic databases, bibliographies of retrieved articles, and personal files were searched and reviewed. Randomized controlled trials (RCTs) of micronutrient supplementation in adult critically ill patients administered enterally and/or parenterally in addition to their routine care were included. Two authors independently extracted data and assessed trial quality. The random-effects model was used to estimate overall relative risk (RR)/mean difference and effect size. P<0.05 was considered statistically significant.
resultsFifteen (n=1714) and 18 (n=1849) RCTs were included for the primary and secondary objectives, respectively. Fourteen trials (n=1468) showed a statistically significant decrease in overall mortality (RR 0.78, 95% confidence interval 0.67-0.90, I2=0%, P=0.0009). Six RCTs (n=1194) indicated a statistically significant decrease in 28-d mortality (RR 0.75, 95% confidence interval 0.63-0.88, I2=0%, P=0.0006). Micronutrient supplementation was not associated with a decrease in infectious complications, length of intensive care unit, or length of hospital stay. In subgroup analyses, a sensitivity analysis of combined micronutrients indicated a significant decrease in mortality (RR 0.69, 95% confidence interval 0.54-0.90, I2=2%, P=0.006). The secondary outcomes confirmed that timing, duration, and dosing appear to be key factors to ensure optimal clinical benefit.
conclusionThis review does suggest a potential benefit of micronutrient supplementation in critically ill adults by possibly being associated with a decrease in mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.