Evidence map›Paper›PMID 21679764›Full record

ArticleReproductive toxicology (Elmsford, N.Y.)2011

Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHβ gene expression by a SirT1-independent pathway in LβT2 gonadotrope cells.

Debin Lan, Min Lu, Shweta Sharma, Pamela L Mellon, Jerrold M Olefsky, Nicholas J G Webster

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive toxicology (Elmsford, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Debin LanDepartment of Medicine, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093, USA.
Min Lu
Shweta Sharma
Pamela L Mellon
Jerrold M Olefsky
Nicholas J G Webster
University of California, San Diego · USVA San Diego Healthcare System · US

Funding

Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
The Interaction of Neuroendocrine Repro. Function and Metabolic SignalingU54HD012303 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MELLON, PAMELA L · 1999 to 2013
$18.0M
Transcriptional Genomics CoreP01DK074868 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLASS, CHRISTOPHER K · 2007 to 2016
$16.6M
PROJECT 3 - Steroid-Metabolic Interactions In the Control of GnRH NeuronsU54HD028934 · NICHD · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI MARSHALL, JOHN C · 1998 to 2013
$16.5M
Testosterone-GnRH Frequency and the Evolution of PCOS in AdolescenceP50HD028934 · NICHD · UNIVERSITY OF VIRGINIA · PI HAISENLEDER, DANIEL J. · 2014 to 2018
$8.6M
The Role of FSH in Female InfertilityP50HD012303 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LAWSON, MARK ANDREW · 1985 to 2020
$7.5M
INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEMR37DK033651 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OLEFSKY, JERROLD MICHAEL · 2000 to 2010
$6.1M
TRAINING IN REPRODUCTIVE SCIENCEST32HD007203 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAMELA L MELLON · 1988 to 2026
$4.8M
INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEMR01DK033651 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OLEFSKY, JERROLD MICHAEL · 1986 to 2013
$2.2M
CELL LINEAGE IN THE ANTERIOR PITUITARYR37HD020377 · NICHD · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI MELLON, PAMELA L · 1996 to 2005
$1.7M
PITUITARY GONADOTROPIN GENE REGULATIONR01HD020377 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MELLON, PAMELA L · 1985 to 2010
$1.5M
GnRH signaling in LbetaT2 gonadotrope cellsR01HD047400 · NICHD · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI WEBSTER, NICHOLAS J · 2005 to 2009
$1.3M
NICHD NIH HHS HD020377NICHD NIH HHS HD28934NICHD NIH HHS P30 HD028934NICHD NIH HHS P50 HD012303NICHD NIH HHS P50 HD028934NICHD NIH HHS R01 HD020377NICHD NIH HHS R01 HD047400NICHD NIH HHS R01S HD047400NICHD NIH HHS R37 HD020377NICHD NIH HHS T32 HD007203NICHD NIH HHS U54 HD012303NICHD NIH HHS U54 HD028934NIDDK NIH HHS DK033651NIDDK NIH HHS DK063491NIDDK NIH HHS DK074868NIDDK NIH HHS P01 DK074868NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK033651NIDDK NIH HHS R37 DK033651
6 · The paper itself

Abstract

Resveratrol (trans-3,5,4'-trihydroxystilbene), a polyphenol found in red wine, has multiple beneficial activities that are similar to caloric restriction. In this study, we analyzed the effect of resveratrol on the gonadotropin genes, follicle-stimulating hormone (FSHβ) and luteinizing hormone (LHβ) in LβT2 immortalized mouse gonadotrope cells. Resveratrol specifically inhibited activin-induced FSHβ mRNA and protein expression, and reduced activin-stimulated Smad2/3 phosphorylation. Knockdown of SirT1 gene expression or SirT1 inhibition did not block repression of FSHβ expression or suppression of Smad2/3 phosphorylation, but did increase p53 acetylation. Taken together, our results suggest that resveratrol down-regulates Smad2/3 phosphorylation and suppresses FSHβ expression via a SirT1-independent pathway.

Indexed as

AnimalsAntioxidantsCell LineFollicle Stimulating Hormone, beta SubunitGene ExpressionGene Expression ProfilingGonadotrophsMiceOligonucleotide Array Sequence AnalysisPhosphorylationResveratrolRNA, MessengerSirtuin 1Smad2 ProteinSmad3 ProteinStilbenesAntioxidantsFollicle Stimulating Hormone, beta SubunitResveratrolRNA, MessengerSirt1 protein, mouseSirtuin 1Smad2 ProteinSmad2 protein, mouseSmad3 ProteinSmad3 protein, mouseStilbenes

Identifiers

PMID21679764
PMCPMC3155991
OpenAlexW1968608855

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.