ArticleThe New phytologist2011
MtbHLH1, a bHLH transcription factor involved in Medicago truncatula nodule vascular patterning and nodule to plant metabolic exchanges.
Article in The New phytologist, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 64 citations in OpenAlex.
- Molecular cartography of root nodule organogenesis: insights into the role of transcription factors.Plant molecular biology · 2026Review
- Organized peripheral vascular strand development in nodules is controlled by a bHLH/HLH heterodimer.The New phytologist · 2026Article
- Phosphate deficiency reduces nodule formation through a phosphate starvation response-like protein in Phaseolus vulgaris.Plant & cell physiology · 2025Article
- Phloem-specific translational regulation of soybean nodulation: Insights from a phloem-targeted TRAP-seq approach.Plant physiology · 2025Article
- Comparative transcriptomics reveals differential carbohydrate and lipid metabolism in roots and nodules of Rhizobia-Inoculated alfalfa (Medicago sativa L.).BMC plant biology · 2025Article
- Unveiling the regulatory mechanisms of nodules development and quality formation in Panax notoginseng using multi-omics and MALDI-MSI.Journal of advanced research · 2025Article
- Genome-wide identification and expression analysis of soybean bHLH transcription factor and its molecular mechanism on grain protein synthesis.Frontiers in plant science · 2025Article
- Arbuscular-Mycorrhizal Symbiosis inInternational journal of molecular sciences · 2023Article
- A Novel bHLH Transcription Factor PtrbHLH66 from Trifoliate Orange Positively Regulates Plant Drought Tolerance by Mediating Root Growth and ROS Scavenging.International journal of molecular sciences · 2022Article
- CROWN ROOTLESS1 binds DNA with a relaxed specificity and activates OsROP and OsbHLH044 genes involved in crown root formation in rice.The Plant journal : for cell and molecular biology · 2022Article
- Heterologous Expression of Dehydration-InducibleInternational journal of molecular sciences · 2022Article
- Gene Expression in Nitrogen-Fixing Symbiotic Nodule Cells inThe Plant cell · 2020Review
- Celebrating 20 Years of Genetic Discoveries in Legume Nodulation and Symbiotic Nitrogen Fixation.The Plant cell · 2020Review
- Transcription Factor bHLH2 RepressesPlant physiology · 2019Article
- Transcription factors network in root endosymbiosis establishment and development.World journal of microbiology & biotechnology · 2018Review
- Article
- Transcriptome analysis of two recombinant inbred lines of common bean contrasting for symbiotic nitrogen fixation.PloS one · 2017Article
- Wheat bHLH-type transcription factor gene TabHLH1 is crucial in mediating osmotic stresses tolerance through modulating largely the ABA-associated pathway.Plant cell reports · 2016Article
- Article
- A transcriptomic analysis of bermudagrass (Cynodon dactylon) provides novel insights into the basis of low temperature tolerance.BMC plant biology · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed at defining the role of a basic helix-loop-helix (bHLH) transcription factor gene from Medicago truncatula, MtbHLH1, whose expression is upregulated during the development of root nodules produced upon infection by rhizobia bacteria. We used MtbHLH1 promoter::GUS fusions and quantitative reverse-transcription polymerase chain reaction analyses to finely characterize the MtbHLH1 expression pattern. We altered MtbHLH1 function by expressing a dominantly repressed construct (CRES-T approach) and looked for possible MtbHLH1 target genes by transcriptomics. We found that MtbHLH1 is expressed in nodule primordia cells derived from pericycle divisions, in nodule vascular bundles (VBs) and in uninfected cells of the nitrogen (N) fixation zone. MtbHLH1 is also expressed in root tips, lateral root primordia cells and root VBs, and induced upon auxin treatment. Altering MtbHLH1 function led to an unusual phenotype, with a modified patterning of nodule VB development and a reduced growth of aerial parts of the plant, even though the nodules were able to fix atmospheric N. Several putative MtbHLH1 regulated genes were identified, including an asparagine synthase and a LOB (lateral organ boundary) transcription factor. Our results suggest that the MtbHLH1 gene is involved in the control of nodule vasculature patterning and nutrient exchanges between nodules and roots.
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