SynthesisBritish journal of clinical pharmacology2011
The association between antipsychotic agents and the risk of myocardial infarction: a systematic review.
Synthesis in British journal of clinical pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Antipsychotic drug use and risk of stroke and myocardial infarction: a systematic review and meta-analysis.BMC psychiatry · 2019Pooled it
- Use of antipsychotics and risk of myocardial infarction: a systematic review and meta-analysis.British journal of clinical pharmacology · 2016Pooled it
- Pooled it
- Prevalence and patient characteristics associated with cardiovascular disease risk factor screening in UK primary care for people with severe mental illness: an electronic healthcare record study.BMJ mental health · 2025Article
- Incidence and Risk of Cardiovascular Outcomes in Patients With Anorexia Nervosa.JAMA network open · 2024Article
- NHS Health Checks for people with mental ill-health 2013-2017: an observational study.Epidemiology and psychiatric sciences · 2020 · on this mapObservational
- Antipsychotic drug exposure and risk of myocardial infarction.Epidemiology and psychiatric sciences · 2017Article
- Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2015Article
- Antipsychotic drugs and risks of myocardial infarction: a self-controlled case series study.European heart journal · 2015Observational
- Cardiovascular and cerebrovascular risk factors and events associated with second-generation antipsychotic compared to antidepressant use in a non-elderly adult sample: results from a claims-based inception cohort study.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2015Article
- Article
- The toxicology and comorbidities of fatal cases involving quetiapine.Forensic science, medicine, and pathology · 2013Article
- Ethnic differences in primary care management of diabetes and cardiovascular disease in people with serious mental illness.The British journal of general practice : the journal of the Royal College of General Practitioners · 2012Article
- Adverse drug events as a cause of hospitalization in older adults.Drug safety · 2012Review
- Article
- Effect of antipsychotic medication use and type on mortality and cardiovascular risks in nursing home patients with dementia.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
aimPatient populations that are prescribed antipsychotic agents have higher cardiovascular mortality rates. The risk of myocardial infarction is influenced by various factors that are more prevalent in patients with a mental illness. The aim of this review was to determine whether the use of antipsychotic agents is associated with the incidence of myocardial infarction in adults.
methodsUsing multiple sources, all studies of antipsychotic agents using myocardial infarction as primary or secondary outcome measures were considered for inclusion. Study populations were adult subjects who had been prescribed an antipsychotic agent at least once in their medical history.
resultsIt total, five studies were identified. Four studies with small numbers of events reported a moderate to strong effect of typical antipsychotic agents on the risk of myocardial infarction. The largest study had a favourable internal validity compared with all other studies and reported no association between the risk of myocardial infarction and current use of either atypical (relative risk 0.98, 95% confidence interval [CI] 0.88, 1.09) or typical antipsychotic agents (relative risk 0.99, 95% CI 0.96, 1.03).
conclusionClinical and methodological heterogeneity between the studies in this review led to an inconclusive answer to the question whether the use of antipsychotics is associated with the incidence of myocardial infarction in adults. Whilst results conflicted, the largest study did not find an association between the use of antipsychotic agents and an increased risk of myocardial infarction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.