ArticleJournal of neurochemistry2011
Sleep duration varies as a function of glutamate and GABA in rat pontine reticular formation.
Article in Journal of neurochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 69 citations in OpenAlex.
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- Pharmacological intervention of behavioural traits and brain histopathology of prenatal valproic acid-induced mouse model of autism.PloS one · 2024Article
- Novel Multi-Strain E3 Probiotic Formulation Improved Mental Health Symptoms and Sleep Quality in Hong Kong Chinese.Nutrients · 2023Article
- Metabotropic glutamate receptor function and regulation of sleep-wake cycles.International review of neurobiology · 2023Article
- Literature Cases Summarized Based on Their Polysomnographic Findings in Rett Syndrome.International journal of environmental research and public health · 2022Review
- Zebrafish as a Tool in the Study of Sleep and Memory-related Disorders.Current neuropharmacology · 2022Review
- A Dichotomous Role for FABP7 in Sleep and Alzheimer's Disease Pathogenesis: A Hypothesis.Frontiers in neuroscience · 2022Article
- Neurobiology of sleep (Review).Experimental and therapeutic medicine · 2021Review
- Dynamic Tracking Algorithm for Time-Varying Neuronal Network Connectivity using Wide-Field Optical Image Video Sequences.Scientific reports · 2020Article
- Sleep and Microdialysis: An Experiment and a Systematic Review of Histamine and Several Amino Acids.Journal of circadian rhythms · 2019Article
- Metabolomic analysis of mouse prefrontal cortex reveals upregulated analytes during wakefulness compared to sleep.Scientific reports · 2018Article
- Location of the Mesopontine Neurons Responsible for Maintenance of Anesthetic Loss of Consciousness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Brain injury unmasking Ehlers-Danlos syndromes after trauma: the fiber print.Orphanet journal of rare diseases · 2016Article
- Article
- Amine Analysis Using AlexaFluor 488 Succinimidyl Ester and Capillary Electrophoresis with Laser-Induced Fluorescence.Journal of analytical methods in chemistry · 2015Article
- GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation.The European journal of neuroscience · 2014Article
- Article
- Sleep and Anesthesia Interactions: A Pharmacological Appraisal.Current anesthesiology reports · 2013Article
- Synthesis and proton NMR spectroscopy of intra-vesicular gamma-aminobutyric acid (GABA).Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The oral part of the pontine reticular formation (PnO) is a component of the ascending reticular activating system and plays a role in the regulation of sleep and wakefulness. The PnO receives glutamatergic and GABAergic projections from many brain regions that regulate behavioral state. Indirect, pharmacological evidence has suggested that glutamatergic and GABAergic signaling within the PnO alters traits that characterize wakefulness and sleep. No previous studies have simultaneously measured endogenous glutamate and GABA from rat PnO in relation to sleep and wakefulness. The present study utilized in vivo microdialysis coupled on-line to capillary electrophoresis with laser-induced fluorescence to test the hypothesis that concentrations of glutamate and GABA in the PnO vary across the sleep/wake cycle. Concentrations of glutamate and GABA were significantly higher during wakefulness than during non-rapid eye movement sleep and rapid eye movement sleep. Regression analysis revealed that decreases in glutamate and GABA accounted for a significant portion of the variance in the duration of non-rapid eye movement sleep and rapid eye movement sleep episodes. These data provide novel support for the hypothesis that endogenous glutamate and GABA in the PnO contribute to the regulation of sleep duration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.