Evidence map›Paper›PMID 21679115›Full record

ReviewExpert review of proteomics2011

Advantages of mRNA display selections over other selection techniques for investigation of protein-protein interactions.

Hui Wang, Rihe Liu

Abstract readReview
In one paragraph

Review in Expert review of proteomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Review
  3. A functional helix shuffled variant of the B domain of Staphylococcus aureus.Protein science : a publication of the Protein Society · 2025
    Article
  4. Review
  5. Chimeric Protein Switch Biosensors.Advances in biochemical engineering/biotechnology · 2024
    Review
  6. Review
  7. Progresses in Cell-Free In Vitro Evolution.Advances in biochemical engineering/biotechnology · 2023
    Review
  8. Applications of nanobodies in brain diseases.Frontiers in immunology · 2022
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. ACS synthetic biology · 2020
    Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Peptide aptamers: development and applications.Current topics in medicinal chemistry · 2015
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hui WangUniversity of North Carolina, Chapel Hill, NC 27599-7568, USA.
Rihe Liu

Funding

"Smart" Nanoparticles for Cancer Therapy and ImagingU54CA119343 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JULIANO, RUDOLPH · 2005 to 2009
$18.3M
Translational Nanosystems for Improved Lung Cancer Treatment with Small MoleculesU54CA151652 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DESIMONE, JOSEPH M. · 2010 to 2014
$12.1M
Identification of Caspase Substrates from Human ProteomeR01NS047650 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, RIHE · 2004 to 2008
$1.4M
Identification of the Interactome of Methylated Histones from Human ProteomeR21DA025702 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, RIHE · 2008 to 2009
$647k
NCI NIH HHS CA119343NCI NIH HHS CA151652NCI NIH HHS U54 CA151652NIDA NIH HHS DA025702NINDS NIH HHS NS047650
6 · The paper itself

Abstract

mRNA display is a genotype-phenotype conjugation method that allows for amplification-based, iterative rounds of in vitro selection to be applied to peptides and proteins. mRNA display can be used to display both long natural protein and short synthetic peptide libraries with unusually high diversities for the investigation of protein-protein interactions. Here, we summarize the advantages of mRNA display by comparing it with other widely used peptide or protein-selection techniques, and discuss various applications of this technique in studying protein-protein interactions.

Indexed as

RNA, MessengerAnimalsHumansPeptide LibraryProtein BindingPeptide LibraryRNA, Messenger

Identifiers

PMID21679115
PMCPMC7103729

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.