SynthesisThe Cochrane database of systematic reviews2011
Symptomatic oxygen for non-hypoxaemic chronic obstructive pulmonary disease.
Synthesis in The Cochrane database of systematic reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- [Oxygen in the acute care of adults : Short version of the German S3 guideline].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2022Guideline
- Oxygen for breathlessness in patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy.The Cochrane database of systematic reviews · 2016Pooled it
- Opioids for the palliation of refractory breathlessness in adults with advanced disease and terminal illness.The Cochrane database of systematic reviews · 2016Pooled it
- [Pharmacological therapy of refractory dyspnoea : a systematic literature review].Schmerz (Berlin, Germany) · 2012Pooled it
- Oxygen therapy for pneumonia in adults.The Cochrane database of systematic reviews · 2012Pooled it
- Effect of palliative oxygen versus room air in relief of breathlessness in patients with refractory dyspnoea: a double-blind, randomised controlled trial.Lancet (London, England) · 2010Trial
- Changes in cerebral oxygenation during sit-to-stand test in COPD patients compared to controls and the effect of oxygen supplementation.ERJ open research · 2026Article
- Oxygen therapy in acute hypoxemic respiratory failure: guidelines from the SRLF-SFMU consensus conference.Annals of intensive care · 2024Article
- Is Structured Exercise Performed with Supplemental Oxygen a Promising Method of Personalized Medicine in the Therapy of Chronic Diseases?Journal of personalized medicine · 2020Article
- Activity-related dyspnea in chronic obstructive pulmonary disease: physical and psychological consequences, unmet needs, and future directions.International journal of chronic obstructive pulmonary disease · 2019Review
- The Breathing, Thinking, Functioning clinical model: a proposal to facilitate evidence-based breathlessness management in chronic respiratory disease.NPJ primary care respiratory medicine · 2017Review
- Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: a cohort study.BMC pulmonary medicine · 2016Observational
- Symptom management in the older adult: 2015 update.Clinics in geriatric medicine · 2015Review
- Evaluation of oxygen prescription in relation to hospital admission rate in patients with chronic obstructive pulmonary disease.BMC pulmonary medicine · 2014Article
- Managing breathlessness in advanced disease.Clinical medicine (London, England) · 2014Article
- Oxygen therapy in acute exacerbations of chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2014Review
- Evidence-based intervention for chronic refractory breathlessness: practical therapies that make a difference.The British journal of general practice : the journal of the Royal College of General Practitioners · 2013Article
- Guidelines for diagnosis and management of chronic obstructive pulmonary disease: Joint ICS/NCCP (I) recommendations.Lung India : official organ of Indian Chest Society · 2013Article
- Long-term oxygen therapy for patients with chronic obstructive pulmonary disease (COPD): an evidence-based analysis.Ontario health technology assessment series · 2012Review
- Predictors of chronic breathlessness: a large population study.BMC public health · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDyspnoea is a common symptom in chronic obstructive pulmonary disease (COPD). People who are hypoxaemic may be given long-term oxygen relief therapy (LTOT) to improve their life expectancy and quality of life. However, the symptomatic benefit of home oxygen therapy in mildly or non-hypoxaemic people with COPD with dyspnoea who do not meet international funding criteria for LTOT (PaO(2)< 55 mmHg or other special cases) is unknown.
objectivesTo determine the efficacy of oxygen versus medical air for relief of subjective dyspnoea in mildly or non-hypoxaemic people with COPD who would not otherwise qualify for home oxygen therapy. The main outcome was patient-reported dyspnoea and secondary outcome was exercise tolerance. SEARCH STRATEGY: We searched the Cochrane Airways Group Register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and EMBASE, to November 2009, to identify randomised controlled trials. We handsearched reference lists of included articles. SELECTION CRITERIA: We only included randomised controlled trials of oxygen versus medical air in mildly or non-hypoxaemic people with COPD. Two review authors independently assessed articles for inclusion. DATA COLLECTION AND ANALYSIS: One review author completed data extraction and methodological quality assessment. A second review author then over-read evidence tables to assess for accuracy. MAIN
resultsTwenty-eight trials on 702 patients met the criteria for inclusion; 18 trials (431 participants) were included in the meta-analysis. Oxygen reduced dyspnoea with a standardised mean difference (SMD) of -0.37 (95% confidence interval (CI) -0.50 to -0.24, P < 0.00001). We observed significant heterogeneity. AUTHORS'
conclusionsOxygen can relieve dyspnoea in mildly and non-hypoxaemic people with COPD who would not otherwise qualify for home oxygen therapy. Given the significant heterogeneity among the included studies, clinicians should continue to evaluate patients on an individual basis until supporting data from ongoing, large randomised controlled trials are available.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.