ReviewJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2011
Metallothionein and brain inflammation.
Review in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Metallothioneins in the Pathogenesis of Liver Diseases: A Review.International journal of hepatology · 2025Review
- Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice.iScience · 2024Article
- Using Redox Proteomics to Gain New Insights into Neurodegenerative Disease and Protein Modification.Antioxidants (Basel, Switzerland) · 2024Review
- Metallothionein expression in the central nervous system in response to chronic heavy metal exposure: possible neuroprotective mechanism.Environmental geochemistry and health · 2023Article
- Zinc and Central Nervous System Disorders.Nutrients · 2023Review
- Oxidative stress and neuroimmune proteins in a mouse model of autism.Cell stress & chaperones · 2023Article
- Importance of Genetic Polymorphisms inInternational journal of molecular sciences · 2021Article
- The Function of Transthyretin Complexes with Metallothionein in Alzheimer's Disease.International journal of molecular sciences · 2020Review
- Review
- CuFrontiers in neuroscience · 2018Article
- Zinc Signal in Brain Diseases.International journal of molecular sciences · 2017Review
- Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies.Frontiers in neuroscience · 2017Review
- Role of Metallothionein in Post-Burn Inflammation.Inflammation · 2016Article
- Copper at the Fungal Pathogen-Host Axis.The Journal of biological chemistry · 2015Review
- Metallothionein ameliorates burn sepsis partly via activation of Akt signaling pathway in mice: a randomized animal study.World journal of emergency surgery : WJES · 2015Article
- Metallothionein and stress combine to affect multiple organ systems.Cell stress & chaperones · 2014Review
- Quantitation of human metallothionein isoforms: a family of small, highly conserved, cysteine-rich proteins.Molecular & cellular proteomics : MCP · 2014Article
- Glia and zinc in ageing and Alzheimer's disease: a mechanism for cognitive decline?Frontiers in aging neuroscience · 2014Review
- Two metallothionein genes in Oxya chinensis: molecular characteristics, expression patterns and roles in heavy metal stress.PloS one · 2014Article
- The role of intracellular zinc release in aging, oxidative stress, and Alzheimer's disease.Frontiers in aging neuroscience · 2014Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the seminal discoveries of Bert Vallee regarding zinc and metallothioneins (MTs) more than 50 years ago, thousands of studies have been published concerning this fascinating story. One of the most active areas of research is the involvement of these proteins in the inflammatory response in general, and in neuroinflammation in particular. We describe the general aspects of the inflammatory response, highlighting the essential role of the major cytokine interleukin-6, and review briefly the expression and function of MTs in the central nervous system in the context of neuroinflammation. Particular attention is paid to the Tg2576 Alzheimer disease mouse model and the preliminary results obtained in mice into which human Zn(7)MT-2A was injected, which suggest a reversal of the behavioral deficits while enhancing amyloid plaque load and gliosis.
Indexed as
Identifiers
21678079What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.