Evidence map›Paper›PMID 21677985›Full record

ArticleChemical communications (Cambridge, England)2011

Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors.

Jody L Major Jourden, Kevin B Daniel, Seth M Cohen

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Selective Iridium-Catalyzed Reductive Amination Inside Living Cells.Journal of the American Chemical Society · 2025
    Article
  2. Article
  3. Review
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  7. Article
  8. Article
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  11. Review
  12. Article
  13. Article
  14. Exploring hydrogen peroxide responsive thiazolidinone-based prodrugs.Chemical communications (Cambridge, England) · 2015
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jody L Major JourdenDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0358, USA.
Kevin B Daniel
Seth M Cohen

Funding

HEMOGLOBIN AND BLOOD PROTEIN CHEMISTRYT32DK007233 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIVES, ELIZABETH A. · 1986 to 2012
$4.6M
Insight and Optimization of Metalloprotein InhibitorsR01GM098435 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THEODORAKIS, EMMANUEL A · 2011 to 2018
$2.2M
New Strategies and Screening Methods for Metalloproteinase InhibitionR21HL094571 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COHEN, SETH M · 2009 to 2010
$373k
NHLBI NIH HHS R21 HL094571NIDDK NIH HHS 5T32-DK007233NIGMS NIH HHS R01 GM098435
6 · The paper itself

Abstract

A series of self-immolative boronic ester protected methyl salicylates and metal-binding groups with various linking strategies have been investigated for their use in the design of matrix metalloproteinase proinhibitors.

Indexed as

Drug DesignMatrix Metalloproteinase InhibitorsHydrogen PeroxideMatrix MetalloproteinasesMetalsProtease InhibitorsHydrogen PeroxideMatrix Metalloproteinase InhibitorsMatrix MetalloproteinasesMetalsProtease Inhibitors

Identifiers

PMID21677985
PMCPMC3682828

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.