ArticleWorld journal of gastroenterology2011
Enhanced proliferation, invasion, and epithelial-mesenchymal transition of nicotine-promoted gastric cancer by periostin.
Article in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- lncRNA DUXAP8 Facilitates Multiple Malignant Phenotypes and Resistance to PARP Inhibitor in HCC via Upregulating FOXM1.Molecular therapy oncolytics · 2020Article
- Self-Perceived Oral Symptoms Associated with Nicotine Replacement Therapy.Oral health & preventive dentistry · 2020Article
- Mechanisms of peritoneal dissemination in gastric cancer.Oncology letters · 2017Article
- The Roles of Matricellular Proteins in Oncogenic Virus-Induced Cancers and Their Potential Utilities as Therapeutic Targets.International journal of molecular sciences · 2017Review
- Association between periostin and epithelial-mesenchymal transition in esophageal squamous cell carcinoma and its clinical significance.Oncology letters · 2017Article
- Snail-Modulated MicroRNA 493 Forms a Negative Feedback Loop with the Insulin-Like Growth Factor 1 Receptor Pathway and Blocks Tumorigenesis.Molecular and cellular biology · 2017Article
- Role of periostin in esophageal, gastric and colon cancer.Oncology letters · 2016Article
- Isoprenaline Induces Periostin Expression in Gastric Cancer.Yonsei medical journal · 2016Article
- p73 promotes glioblastoma cell invasion by directly activating POSTN (periostin) expression.Oncotarget · 2016Article
- Nicotine Inhibits Cisplatin-Induced Apoptosis via Regulating α5-nAChR/AKT Signaling in Human Gastric Cancer Cells.PloS one · 2016Article
- RNA-directed epigenetic silencing of Periostin inhibits cell motility.Royal Society open science · 2015Article
- Periostin expression and its prognostic value for colorectal cancer.International journal of molecular sciences · 2015Article
- Role of periostin and its antagonist PNDA-3 in gastric cancer metastasis.World journal of gastroenterology · 2015Review
- Detection and screening of small molecule agents for overcoming Sorafenib resistance of hepatocellular carcinoma: a bioinformatics study.International journal of clinical and experimental medicine · 2015Article
- Smoking affects treatment outcome in patients with resected esophageal squamous cell carcinoma who received chemotherapy.PloS one · 2015Article
- Nicotine upregulates microRNA-21 and promotes TGF-β-dependent epithelial-mesenchymal transition of esophageal cancer cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Celecoxib regulates apoptosis and autophagy via the PI3K/Akt signaling pathway in SGC-7901 gastric cancer cells.International journal of molecular medicine · 2014Article
- The wound healing, chronic fibrosis, and cancer progression triad.Physiological genomics · 2014Review
- Upregulation of periostin prevents P53-mediated apoptosis in SGC-7901 gastric cancer cells.Molecular biology reports · 2013Article
- Toxicity of nicotine by repeated intratracheal instillation to f344 rats.Journal of toxicologic pathology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the contribution of periostin in nicotine-promoted gastric cancer cell proliferation, survival, invasion, drug resistance, and epithelial-mesenchymal transition (EMT).
methodsGastric cancer cells were treated with nicotine and periostin protein expression was determined by immunoblotting. Periostin mRNA in gastric cancer cells was silenced using small interfering RNA (siRNA) techniques and periostin gene expression was evaluated by quantitative reverse transcription-polymerase chain reaction. Gastric cancer cells transfected with control or periostin siRNA plasmid were compared in terms of cell proliferation using the methylthiazolyldiphenyl-tetrazolium bromide assay. Cell apoptosis was compared using annexin V-fluoresceine isothiocyanate and propidium iodine double staining. Tumor invasion was determined using the Boyden chamber invasion assay, and the EMT marker Snail expression was evaluated by immunoblotting.
resultsNicotine upregulated periostin in gastric cancer cells through a COX-2 dependent pathway, which was blocked by the COX-2-specific inhibitor NS398. Periostin mRNA expression was decreased by ~87.2% by siRNA in gastric cancer cells, and stable periostin-silenced cells were obtained by G418 screening. Periostin-silenced gastric cancer cells exhibited reduced cell proliferation, elevated sensitivity to chemotherapy with 5-fluorouracil, and decreased cell invasion and Snail expression (P < 0.05).
conclusionPeriostin is a nicotine target gene in gastric cancer and plays a role in gastric cancer cell growth, invasion, drug resistance, and EMT facilitated by nicotine.
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