ArticleAnnals of pediatric cardiology2011
Genes, autoimmunity and pathogenesis of rheumatic heart disease.
Article in Annals of pediatric cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 86 citations in OpenAlex.
- Early Detection and Treatment Opportunities for Children With Subclinical Rheumatic Heart Disease.Journal of the American Heart Association · 2026Article
- Immune cells and rheumatic heart disease: A 2-sample and Bayesian weighted Mendelian randomization study.Medicine · 2026Article
- Diagnostic test accuracy of simplified algorithms for diagnosing acute rheumatic fever: a systematic review.Communications medicine · 2025Article
- The Burden of Rheumatic Chorea in the Modern Era: A Case Series From a Tertiary Health Care Center in South India.Journal of movement disorders · 2025Article
- Evaluation of Ficolin-3 deficiency as a risk factor in the development of rheumatic heart disease.BMC research notes · 2025Article
- T-Cell Receptor Sequences Identify Combined Coxsackievirus-International journal of molecular sciences · 2024Article
- Exploring gut microbiota's role in rheumatic valve disease: insights from a Mendelian randomization study and mediation analysis.Frontiers in immunology · 2024Article
- The Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases?Medicina (Kaunas, Lithuania) · 2023Review
- Article
- Profiling system-wide variations and similarities between Rheumatic Heart Disease and Acute Rheumatic Fever-A pilot analysis.PLoS neglected tropical diseases · 2023Article
- Recent Advances in the Rheumatic Fever and Rheumatic Heart Disease Continuum.Pathogens (Basel, Switzerland) · 2022Review
- IgG2 rules: N-acetyl-β-D-glucosamine-specific IgG2 and Th17/Th1 cooperation may promote the pathogenesis of acute rheumatic heart disease and be a biomarker of the autoimmune sequelae ofFrontiers in cardiovascular medicine · 2022Article
- The Genetic Control of the Rheumatic Heart: Closing the Genotype-Phenotype Gap.Frontiers in medicine · 2021Review
- Pattern of Cardiac Diseases and Co-Existing Morbidities Among Newly Registered Cardiac Patients in an Adult Cardiac Referral Clinic of Hawassa University Comprehensive Specialized Hospital, Southern-Ethiopia.Vascular health and risk management · 2020Article
- Angiotensin Converting Enzyme Inhibitors (ACEIs) Decrease the Progression of Cardiac Fibrosis in Rheumatic Heart Disease Through the Inhibition of IL-33/sST2.Frontiers in cardiovascular medicine · 2020Review
- Throat Colonization and Antibiotic Susceptibility of Group a β-Hemolytic Streptococci Among Rheumatic Heart Disease Patients Attending a Cardiac Referral Hospital in Tanzania, a Descriptive Cross-Sectional Study.Frontiers in surgery · 2020Article
- Mitochondrial DNA Mutations and Rheumatic Heart Diseases.Journal of cardiovascular development and disease · 2019Article
- Health Challenges of the Pacific Region: Insights From History, Geography, Social Determinants, Genetics, and the Microbiome.Frontiers in immunology · 2019Review
- T cell subsets: an integral component in pathogenesis of rheumatic heart disease.Immunologic research · 2018Review
- Rheumatic heart disease in North Darfur: an alarmingly high burden and control initiative.Sudanese journal of paediatrics · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathogenesis of rheumatic heart disease (RHD) remains incompletely understood. Several genes associated with RHD have been described; most of these are involved with immune responses. Single nucleotide polymorphisms in a number of genes affect patients with RHD compared to controls. Molecular mimicry between streptococcal antigens and human proteins, including cardiac myosin epitopes, vimentin and other intracellular proteins is central to the pathogenesis of RHD. Autoreactive T cells migrate from the peripheral blood to the heart and proliferate in the valves in response to stimulation with specific cytokines. The types of cells involved in the inflammation as well as different cytokine profiles in these patients are being investigated. High TNF alpha, interferon gamma, and low IL4 are found in the rheumatic valve suggesting an imbalance between Th1 and Th2 cytokines and probably contributing to the progressive and permanent valve damage. Animal model of ARF in the Lewis rat may further contribute towards understanding the ARF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.