ArticleMolecular vision2011
Mitochondrial DNA lineages of African origin confer susceptibility to primary open-angle glaucoma in Saudi patients.
Article in Molecular vision, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Beyond prevalence: diagnostic heterogeneity in population-based glaucoma studies in Africa-a systematic review.Frontiers in medicine · 2026Pooled it
- Psychological distress and psychosocial care in adults with glaucoma in Africa: A systematic review protocol.PloS one · 2026Article
- Review
- How "Omics" Studies Contribute to a Better Understanding of Fuchs' Endothelial Corneal Dystrophy.Current issues in molecular biology · 2025Review
- Features Associated with Visible Lamina Cribrosa Pores in Individuals of African Ancestry with Glaucoma: Primary Open-Angle African Ancestry Glaucoma Genetics (POAAGG) Study.Vision (Basel, Switzerland) · 2024Article
- The Role of Genetic Ancestry as a Risk Factor for Primary Open-angle Glaucoma in African Americans.Investigative ophthalmology & visual science · 2021Article
- Mitochondrial Genome Study Identifies Association Between Primary Open-Angle Glaucoma and Variants inFrontiers in genetics · 2021Article
- Mitochondria: The Retina's Achilles' Heel in AMD.Advances in experimental medicine and biology · 2021Article
- The association of mitochondrial DNA haplogroups with POAG in African Americans.Experimental eye research · 2019Article
- Mitochondrial haplogroup L1c2 is associated with increased disease severity in African American patients with primary open-angle glaucoma.Journal of clinical & experimental ophthalmology · 2019Article
- Mitochondrial DNA Variation and Disease Susceptibility in Primary Open-Angle Glaucoma.Investigative ophthalmology & visual science · 2018Article
- Glaucoma Features in an East African Population: A 6-Year Cohort Study of Older Adults in Nakuru, Kenya.Journal of glaucoma · 2018Article
- The genetic mechanisms of primary angle closure glaucoma.Eye (London, England) · 2015Review
- Mitochondrial haplogroups are associated with severity of diabetic retinopathy.Investigative ophthalmology & visual science · 2014Article
- Mitochondrial polymorphism A10398G and Haplogroup I are associated with Fuchs' endothelial corneal dystrophy.Investigative ophthalmology & visual science · 2014Article
- Total antioxidant level is correlated with intra-ocular pressure in patients with primary angle closure glaucoma.BMC research notes · 2014Article
- A catalase promoter variant rs1001179 is associated with visual acuity but not with primary angle closure glaucoma in Saudi patients.BMC medical genetics · 2013Article
- Mitochondrial DNA haplogroups confer differences in risk for age-related macular degeneration: a case control study.BMC medical genetics · 2013Article
- Mitochondrial sequence variation in African-American primary open-angle glaucoma patients.PloS one · 2013Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe previously reported that certain mitochondrial DNA (mtDNA) polymorphisms in the coding region may be involved in the pathogenesis for primary open-angle-glaucoma (POAG). This encouraged us to extend our work and assess whether mtDNA diagnostic polymorphisms, defining geographically structured haplogroups, could be associated with the development of POAG.
methodsWe sequenced the mtDNA regulatory hypervariable region-I (HVS-I) region and coding regions, comprising haplogroup diagnostic polymorphisms, in 176 POAG patients and 186 matched healthy controls (free of glaucoma by examination) of Saudi Arabia ascendancy. A large sample of 810 healthy Saudi Arabs representing the general Saudi population has also been included in the analysis. Assigning individuals into various mitochondrial haplogroups was performed using the nomenclature previously described for African and for Eurasian sequences.
resultsAfrican mtDNA haplotypes belonging to L haplogroups, excluding L2, confer susceptibility to POAG whereas the Eurasian haplogroup N1 was associated with reduced risk of developing POAG in Saudi Arabian population.
conclusionsSaudi individuals with mtDNA of African origin are at higher risk of developing POAG. In addition, the mtDNA Eurasian haplogroup N1 may play a mild protective effect to this illness.
Indexed as
Identifiers
21677789PMC3110492W1485820439What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.