Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2011
Identifying neurobiological phenotypes associated with alcohol use disorder severity.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03842670 (Neurocognitive and Neurobehavioral Mechanisms of Change Following Psychological), which is not on this map. Cited by 134 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neurocognitive and Neurobehavioral Mechanisms of Change Following Psychological
Who cites it
134 citing papers in PubMed, 6 syntheses or guidelines pooled it, 251 citations in OpenAlex.
- A voxel-wise meta-analysis of task-based functional MRI studies on impaired gain and loss processing in adults with addiction.Journal of psychiatry & neuroscience : JPN · 2021Pooled it
- How the harm of drugs and their availability affect brain reactions to drug cues: a meta-analysis of 64 neuroimaging activation studies.Translational psychiatry · 2020Pooled it
- Inhalation of Alcohol Vapor: Measurement and Implications.Alcoholism, clinical and experimental research · 2017Pooled it
- The hyper-sentient addict: an exteroception model of addiction.The American journal of drug and alcohol abuse · 2015Pooled it
- The effect of alcohol consumption on the adolescent brain: A systematic review of MRI and fMRI studies of alcohol-using youth.NeuroImage. Clinical · 2014Pooled it
- Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta-analysis and systematic review.Addiction biology · 2013Pooled it
- Across the spectrum: Acute alcohol responses in young adults with mild, moderate, and severe alcohol use disorder.Drug and alcohol dependence · 2025Trial
- Baseline C-reactive protein levels are predictive of treatment response to a neuroimmune modulator in individuals with an alcohol use disorder: a preliminary study.The American journal of drug and alcohol abuse · 2023Trial
- Mindfulness-Based Relapse Prevention and Transcranial Direct Current Stimulation to Reduce Heavy Drinking: A Double-Blind Sham-Controlled Randomized Trial.Alcoholism, clinical and experimental research · 2019Trial
- Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Effects of D-cycloserine on extinction of mesolimbic cue reactivity in alcoholism: a randomized placebo-controlled trial.Psychopharmacology · 2015Trial
- Moderating effect of working memory capacity on acute alcohol effects on BOLD response during inhibition and error monitoring in male heavy drinkers.Psychopharmacology · 2015Trial
- The relationship between years of cocaine use and brain activation to cocaine and response inhibition cues.Addiction (Abingdon, England) · 2014Trial
- Varenicline effects on drinking, craving and neural reward processing among non-treatment-seeking alcohol-dependent individuals.Psychopharmacology · 2014Trial
- Brain regions affected by impaired control modulate responses to alcohol and smoking cues.Journal of studies on alcohol and drugs · 2014Trial
- Subjective responses to alcohol in the lab predict neural responses to alcohol cues.Journal of studies on alcohol and drugs · 2014Trial
- TACR1 genotypes predict fMRI response to alcohol cues and level of alcohol dependence.Alcoholism, clinical and experimental research · 2013Trial
- Sex differences in neural circuits driving binge-like drinking: a female-specific role for an amygdalo-striatal pathway.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Reimagining the Biopsychosocial Model: Transdiagnostic Factors to Precision Psychiatry.Biological psychiatry global open science · 2026Article
- EFFECTS OF TOLL-LIKE RECEPTOR 3 - DEPENDENT IMMUNE ACTIVATION IN MICE ARE SEX- AND TISSUE- SPECIFIC: IMPLICATIONS FOR ALCOHOL USE DISORDER.bioRxiv : the preprint server for biology · 2026Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Although numerous studies provide general support for the importance of genetic factors in the risk for alcohol use disorders (AUDs), candidate gene and genome-wide studies have yet to identify a set of genetic variations that explain a significant portion of the variance in AUDs. One reason is that alcohol-related phenotypes used in genetic studies are typically based on highly heterogeneous diagnostic categories. Therefore, identifying neurobiological phenotypes related to neuroadaptations that drive the development of AUDs is critical for the future success of genetic and epigenetic studies. One such neurobiological phenotype is the degree to which exposure to alcohol taste cues recruits the basal ganglia, prefrontal cortex, and motor areas, all of which have been shown to have a critical role in addictive behaviors in animal studies. To that end, this study was designed to examine whether cue-elicited responses of these structures are associated with AUD severity in a large sample (n=326) using voxelwise and functional connectivity measures. Results suggested that alcohol cues significantly activated dorsal striatum, insula/orbitofrontal cortex, anterior cingulate cortex, and ventral tegmental area. AUD severity was moderately correlated with regions involved in incentive salience such as the nucleus accumbens and amygdala, and stronger relationships with precuneus, insula, and dorsal striatum. The findings indicate that AUDs are related to neuroadaptations in these regions and that these measures may represent important neurobiological phenotypes for subsequent genetic studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.