ArticleBrain, behavior and evolution2011
Brain transcriptomic response of threespine sticklebacks to cues of a predator.
Article in Brain, behavior and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- The contribution of additive genetic variation to personality variation: heritability of personality.Proceedings. Biological sciences · 2015Pooled it
- Chemical cues and molecular mechanisms suspected in abiotic stress communication.The Journal of experimental biology · 2026Article
- Building neuroanatomical resources for three-spined sticklebacks: Brain areas important for social behavior.bioRxiv : the preprint server for biology · 2026Article
- Managing the tradeoff between reproduction and survival requires flexibility in behaviour and gene regulation in three-spined stickleback.Proceedings. Biological sciences · 2024Article
- Article
- Novel predator-induced phenotypic plasticity by hemoglobin and physiological changes in the brain ofFrontiers in physiology · 2023Article
- Predation impacts brain allometry in female guppies (Evolutionary ecology · 2022Article
- Shedding light on the circadian clock of the threespine stickleback.The Journal of experimental biology · 2021Article
- Back to the basics? Transcriptomics offers integrative insights into the role of space, time and the environment for gene expression and behaviour.Biology letters · 2021Article
- Threespine Stickleback: A Model System For Evolutionary Genomics.Annual review of genomics and human genetics · 2021Review
- Minimally invasive brain injections for viral-mediated transgenesis: New tools for behavioral genetics in sticklebacks.PloS one · 2021Article
- Predation threats for a 24-h period activated the extension of axons in the brains of Xenopus tadpoles.Scientific reports · 2020Article
- Individual variation and the challenge hypothesis.Hormones and behavior · 2020Review
- Prolonged Bat Call Exposure Induces a Broad Transcriptional Response in the Male Fall Armyworm (Frontiers in behavioral neuroscience · 2019Article
- Evolutionary diversity as a catalyst for biological discovery.Integrative zoology · 2018Review
- Genomic tools for behavioural ecologists to understand repeatable individual differences in behaviour.Nature ecology & evolution · 2018Review
- Temporal dynamics of neurogenomic plasticity in response to social interactions in male threespined sticklebacks.PLoS genetics · 2017Article
- Molecular mechanisms and the conflict between courtship and aggression in three-spined sticklebacks.Molecular ecology · 2016Article
- Molecular pathways associated with the nutritional programming of plant-based diet acceptance in rainbow trout following an early feeding exposure.BMC genomics · 2016Article
- Routine handling methods affect behaviour of three-spined sticklebacks in a novel test of anxiety.Behavioural brain research · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Predation pressure represents a strong selective force that influences the development and evolution of living organisms. An increasing number of studies have shown that both environmental and social factors, including exposure to predators, substantially shape the structure and function of the brain. However, our knowledge about the molecular mechanisms underlying the response of the brain to environmental stimuli is limited. In this study, we used whole-genome comparative oligonucleotide microarrays to investigate the brain transcriptomic response to cues of a predator in the threespine stickleback, Gasterosteus aculeatus. We found that repeated exposure to olfactory, visual and tactile cues of a predator (rainbow trout, Oncorrhynchus mykiss) for 6 days resulted in subtle but significant transcriptomic changes in the brain of sticklebacks. Gene functional analysis and gene ontology enrichment revealed that the majority of the transcripts differentially expressed between the fish exposed to cues of a predator and the control group were related to antigen processing and presentation involving the major histocompatibility complex, transmission of synaptic signals, brain metabolic processes, gene regulation and visual perception. The top four identified pathways were synaptic long-term depression, RAN signaling, relaxin signaling and phototransduction. Our study demonstrates that exposure of sticklebacks to cues of a predator results in the activation of a wide range of biological and molecular processes and lays the foundation for future investigations on the molecular factors that modulate the function and evolution of the brain in response to stressors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.