ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Behavioral and in vivo electrophysiological evidence for presymptomatic alteration of prefrontostriatal processing in the transgenic rat model for huntington disease.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Neuroprotective effects of levothyroxine on cognition deficits and memory in an experimental model of Huntington's disease in rats: An electrophysiological study.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Gene-dosage- and sex-dependent differences in the prodromal-Like phase of the F344tgHD rat model for Huntington disease.Frontiers in neuroscience · 2024Article
- Short and long-term evaluation of the impact of proton minibeam radiation therapy on motor, emotional and cognitive functions.Scientific reports · 2020Article
- The Role of Hypothalamic Pathology for Non-Motor Features of Huntington's Disease.Journal of Huntington's disease · 2019Review
- The Disruption of Memory Consolidation of Duration Introduces Noise While Lengthening the Long-Term Memory Representation of Time in Humans.Frontiers in psychology · 2019Article
- The Alteration of Emotion Regulation Precedes the Deficits in Interval Timing in the BACHD Rat Model for Huntington Disease.Frontiers in integrative neuroscience · 2018Article
- Early Alterations in Operant Performance and Prominent Huntingtin Aggregation in a Congenic F344 Rat Line of the Classical CAGFrontiers in neuroscience · 2018Article
- Interactions between medial prefrontal cortex and dorsomedial striatum are necessary for odor span capacity in rats: role of GluN2B-containing NMDA receptors.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control.Nature communications · 2017Article
- Changes in striatal activity and functional connectivity in a mouse model of Huntington's disease.PloS one · 2017Article
- Quantitative Electroencephalographic Biomarkers in Preclinical and Human Studies of Huntington's Disease: Are They Fit-for-Purpose for Treatment Development?Frontiers in neurology · 2017Review
- The amygdalo-nigrostriatal network is critical for an optimal temporal performance.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Corticostriatal Dysfunction in Huntington's Disease: The Basics.Frontiers in human neuroscience · 2016Review
- Impaired Decision Making and Loss of Inhibitory-Control in a Rat Model of Huntington Disease.Frontiers in behavioral neuroscience · 2016Article
- Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Contralateral disconnection of the rat prelimbic cortex and dorsomedial striatum impairs cue-guided behavioral switching.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Infant rats can learn time intervals before the maturation of the striatum: evidence from odor fear conditioning.Frontiers in behavioral neuroscience · 2014Article
- The dopaminergic stabilizer pridopidine increases neuronal activity of pyramidal neurons in the prefrontal cortex.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- Altered diffusion tensor imaging measurements in aged transgenic Huntington disease rats.Brain structure & function · 2013Article
- Modified impact of emotion on temporal discrimination in a transgenic rat model of Huntington disease.Frontiers in behavioral neuroscience · 2013Article
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12 authors.
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Abstract
Cognitive decline precedes motor symptoms in Huntington disease (HD). A transgenic rat model for HD carrying only 51 CAG repeats recapitulates the late-onset HD phenotype. Here, we assessed prefrontostriatal function in this model through both behavioral and electrophysiological assays. Behavioral examination consisted in a temporal bisection task within a supra-second range (2 vs.8 s), which is thought to involve prefrontostriatal networks. In two independent experiments, the behavioral analysis revealed poorer temporal sensitivity as early as 4 months of age, well before detection of overt motor deficits. At a later symptomatic age, animals were impaired in their temporal discriminative behavior. In vivo recording of field potentials in the dorsomedial striatum evoked by stimulation of the prelimbic cortex were studied in 4- to 5-month-old rats. Input/output curves, paired-pulse function, and plasticity induced by theta-burst stimulation (TBS) were assessed. Results showed an altered plasticity, with higher paired-pulse facilitation, enhanced short-term depression, as well as stronger long-term potentiation after TBS in homozygous transgenic rats. Results from the heterozygous animals mostly fell between wild-type and homozygous transgenic rats. Our results suggest that normal plasticity in prefrontostriatal circuits may be necessary for reliable and precise timing behavior. Furthermore, the present study provides the first behavioral and electrophysiological evidence of a presymptomatic alteration of prefrontostriatal processing in an animal model for Huntington disease and suggests that supra-second timing may be the earliest cognitive dysfunction in HD.
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