ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Astrocytes display complex and localized calcium responses to single-neuron stimulation in the hippocampus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 63 citations in OpenAlex.
- Emerging roles of astrocytes in hippocampal circuitry and behavior.Frontiers in cellular neuroscience · 2025Review
- Instructive roles of astrocytes in hippocampal synaptic plasticity: neuronal activity-dependent regulatory mechanisms.The FEBS journal · 2022Review
- Advances and prospects of rhodopsin-based optogenetics in plant research.Plant physiology · 2021Review
- Olfactory bulb astrocytes mediate sensory circuit processing through Sox9 in the mouse brain.Nature communications · 2021Article
- A morphological analysis of activity-dependent myelination and myelin injury in transitional oligodendrocytes.Scientific reports · 2021Article
- Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Using Genetically Encoded Calcium Indicators to Study Astrocyte Physiology: A Field Guide.Frontiers in cellular neuroscience · 2021Article
- Parallel astrocyte calcium signaling modulates olfactory bulb responses.Journal of neuroscience research · 2020Article
- Review
- Article
- Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury.PLoS biology · 2018Article
- Physiology of Astroglia.Physiological reviews · 2018Review
- Pseudo-typed Semliki Forest virus delivers EGFP into neurons.Journal of neurovirology · 2017Article
- Carbenoxolone inhibits Pannexin1 channels through interactions in the first extracellular loop.The Journal of general physiology · 2016Article
- Reciprocal Regulation of Mitochondrial Dynamics and Calcium Signaling in Astrocyte Processes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The role of astrocyte mitochondria in differential regional susceptibility to environmental neurotoxicants: tools for understanding neurodegeneration.Toxicological sciences : an official journal of the Society of Toxicology · 2015Review
- Combining microfluidics, optogenetics and calcium imaging to study neuronal communication in vitro.PloS one · 2015Article
- Glutamate mediated astrocytic filtering of neuronal activity.PLoS computational biology · 2014Article
- A statistical method of identifying interactions in neuron-glia systems based on functional multicell Ca2+ imaging.PLoS computational biology · 2014Article
- Astrocyte calcium signalling orchestrates neuronal synchronization in organotypic hippocampal slices.The Journal of physiology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Astrocytes show a complex structural and physiological interplay with neurons and respond to neuronal activation in vitro and in vivo with intracellular calcium elevations. These calcium changes enable astrocytes to modulate synaptic transmission and plasticity through various mechanisms. However, the response pattern of astrocytes to single neuronal depolarization events still remains unresolved. This information is critical for fully understanding the coordinated network of neuron-glial signaling in the brain. To address this, we developed a system to map astrocyte calcium responses along apical dendrites of CA1 pyramidal neurons in hippocampal slices using single-neuron stimulation with channelrhodopsin-2. This technique allowed selective neuronal depolarization without invasive manipulations known to alter calcium levels in astrocytes. Light-evoked neuronal depolarization was elicited and calcium events in surrounding astrocytes were monitored using the calcium-sensitive dye Calcium Orange. Stimulation of single neurons caused calcium responses in populations of astrocytes along the apical axis of CA1 cell dendrites. Calcium responses included single events that were synchronized with neuronal stimulation and poststimulus changes in calcium event frequency, both of which were modulated by glutamatergic and purinergic signaling. Individual astrocytes near CA1 cells showed low ability to respond to repeated neuronal depolarization events. However, the response of the surrounding astrocyte population was remarkably accurate. Interestingly, the reliability of responses was graded with respect to astrocyte location along the CA1 cell dendrite, with astrocytes residing in the primary dendrite subregion being most responsive. This study provides a new perspective on the dynamic response property of astrocyte ensembles to neuronal activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.